C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes
The influence of aqueous solution of pristine C 60 fullerene (C 60 FAS) on functional activity of lymphocytes from a healthy person was studied for the first time. By means of atomic force microscopy, it was found that C 60 FAS in a concentration of 0.1 mg/ml increases the stiffness of the lymphocyt...
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| Veröffentlicht in: | European biophysics journal 2015-09, Vol.44 (6), p.493-498 |
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| container_title | European biophysics journal |
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| creator | Skorkina, Marina Yu Sladkova, Evgenia A. Shamray, Elena A. Cherkashina, Olga V. Evstigneev, Maxim P. Buchelnikov, Anatoly S. Prylutskyy, Yuriy I. Ritter, Uwe |
| description | The influence of aqueous solution of pristine C
60
fullerene (C
60
FAS) on functional activity of lymphocytes from a healthy person was studied for the first time. By means of atomic force microscopy, it was found that C
60
FAS in a concentration of 0.1 mg/ml increases the stiffness of the lymphocyte membrane by 41 % (
p
|
| doi_str_mv | 10.1007/s00249-015-1050-9 |
| format | Article |
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60
fullerene (C
60
FAS) on functional activity of lymphocytes from a healthy person was studied for the first time. By means of atomic force microscopy, it was found that C
60
FAS in a concentration of 0.1 mg/ml increases the stiffness of the lymphocyte membrane by 41 % (
p
< 0.05) and lowers the functional activity of the plasmalemma surface, thereby constraining the use of its membrane material in physiological reactions using a hypotonic model in vitro. However, a cell retains the ability to regulate its volume and demonstrates relative resistance to hypo-osmotic stress. The resistance of lymphocytes in hypo-osmotic medium is facilitated by activation of the nucleus by C
60
fullerene particles, which regulates the implementation of two consistent phases of an increase and decrease of cell volume, thereby retaining cell viability. All these indicate the impact of C
60
fullerene on the cellular nucleus.</description><identifier>ISSN: 0175-7571</identifier><identifier>EISSN: 1432-1017</identifier><identifier>DOI: 10.1007/s00249-015-1050-9</identifier><identifier>PMID: 26071689</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biophysics Letter ; Cell Biology ; Cells, Cultured ; Elasticity ; Fullerenes - pharmacology ; Humans ; Life Sciences ; Lymphocytes - drug effects ; Lymphocytes - physiology ; Membrane Biology ; Nanotechnology ; Neurobiology ; Osmoregulation</subject><ispartof>European biophysics journal, 2015-09, Vol.44 (6), p.493-498</ispartof><rights>European Biophysical Societies' Association 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2599-ee8ce952c8543674437fde9e37f96239b05f5e2d21608ebff3912b3182ef854c3</citedby><cites>FETCH-LOGICAL-c2599-ee8ce952c8543674437fde9e37f96239b05f5e2d21608ebff3912b3182ef854c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00249-015-1050-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00249-015-1050-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26071689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skorkina, Marina Yu</creatorcontrib><creatorcontrib>Sladkova, Evgenia A.</creatorcontrib><creatorcontrib>Shamray, Elena A.</creatorcontrib><creatorcontrib>Cherkashina, Olga V.</creatorcontrib><creatorcontrib>Evstigneev, Maxim P.</creatorcontrib><creatorcontrib>Buchelnikov, Anatoly S.</creatorcontrib><creatorcontrib>Prylutskyy, Yuriy I.</creatorcontrib><creatorcontrib>Ritter, Uwe</creatorcontrib><title>C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes</title><title>European biophysics journal</title><addtitle>Eur Biophys J</addtitle><addtitle>Eur Biophys J</addtitle><description>The influence of aqueous solution of pristine C
60
fullerene (C
60
FAS) on functional activity of lymphocytes from a healthy person was studied for the first time. By means of atomic force microscopy, it was found that C
60
FAS in a concentration of 0.1 mg/ml increases the stiffness of the lymphocyte membrane by 41 % (
p
< 0.05) and lowers the functional activity of the plasmalemma surface, thereby constraining the use of its membrane material in physiological reactions using a hypotonic model in vitro. However, a cell retains the ability to regulate its volume and demonstrates relative resistance to hypo-osmotic stress. The resistance of lymphocytes in hypo-osmotic medium is facilitated by activation of the nucleus by C
60
fullerene particles, which regulates the implementation of two consistent phases of an increase and decrease of cell volume, thereby retaining cell viability. All these indicate the impact of C
60
fullerene on the cellular nucleus.</description><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Biophysics Letter</subject><subject>Cell Biology</subject><subject>Cells, Cultured</subject><subject>Elasticity</subject><subject>Fullerenes - pharmacology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - physiology</subject><subject>Membrane Biology</subject><subject>Nanotechnology</subject><subject>Neurobiology</subject><subject>Osmoregulation</subject><issn>0175-7571</issn><issn>1432-1017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1OwzAUhS0EglJ4ABbkkSVwbcdxPKKKP6kSCywslutet6mSuNjJ0LfHVQsji4-vfM7R9UfIDYN7BqAeEgAvdQFMFgwkFPqETFgpeJ6YOiWTfMpCScUuyGVKG4BSMlafkwtegWJVrSfka1YB9WPbYsQeqfUe3ZAotjYNjaPbGLYYhwYTtf2ShtSFiKuxtUMTehrRuv0l0eDpeuxsT9tdt10HtxswXZEzb9uE10edks_np4_ZazF_f3mbPc4Lx6XWBWLtUEvualmKSpWlUH6JGrPoigu9AOkl8iVnFdS48F5oxheC1Rx9jjgxJXeH3rzs94hpMF2THLat7TGMyTAFggslQWUrO1hdDClF9GYbm87GnWFg9kjNAanJSM0eqdE5c3usHxcdLv8SvwyzgR8MKT_1K4xmE8bY5y__0_oD6sKBug</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Skorkina, Marina Yu</creator><creator>Sladkova, Evgenia A.</creator><creator>Shamray, Elena A.</creator><creator>Cherkashina, Olga V.</creator><creator>Evstigneev, Maxim P.</creator><creator>Buchelnikov, Anatoly S.</creator><creator>Prylutskyy, Yuriy I.</creator><creator>Ritter, Uwe</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes</title><author>Skorkina, Marina Yu ; Sladkova, Evgenia A. ; Shamray, Elena A. ; Cherkashina, Olga V. ; Evstigneev, Maxim P. ; Buchelnikov, Anatoly S. ; Prylutskyy, Yuriy I. ; Ritter, Uwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2599-ee8ce952c8543674437fde9e37f96239b05f5e2d21608ebff3912b3182ef854c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biophysics</topic><topic>Biophysics Letter</topic><topic>Cell Biology</topic><topic>Cells, Cultured</topic><topic>Elasticity</topic><topic>Fullerenes - pharmacology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - physiology</topic><topic>Membrane Biology</topic><topic>Nanotechnology</topic><topic>Neurobiology</topic><topic>Osmoregulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skorkina, Marina Yu</creatorcontrib><creatorcontrib>Sladkova, Evgenia A.</creatorcontrib><creatorcontrib>Shamray, Elena A.</creatorcontrib><creatorcontrib>Cherkashina, Olga V.</creatorcontrib><creatorcontrib>Evstigneev, Maxim P.</creatorcontrib><creatorcontrib>Buchelnikov, Anatoly S.</creatorcontrib><creatorcontrib>Prylutskyy, Yuriy I.</creatorcontrib><creatorcontrib>Ritter, Uwe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European biophysics journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skorkina, Marina Yu</au><au>Sladkova, Evgenia A.</au><au>Shamray, Elena A.</au><au>Cherkashina, Olga V.</au><au>Evstigneev, Maxim P.</au><au>Buchelnikov, Anatoly S.</au><au>Prylutskyy, Yuriy I.</au><au>Ritter, Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes</atitle><jtitle>European biophysics journal</jtitle><stitle>Eur Biophys J</stitle><addtitle>Eur Biophys J</addtitle><date>2015-09</date><risdate>2015</risdate><volume>44</volume><issue>6</issue><spage>493</spage><epage>498</epage><pages>493-498</pages><issn>0175-7571</issn><eissn>1432-1017</eissn><abstract>The influence of aqueous solution of pristine C
60
fullerene (C
60
FAS) on functional activity of lymphocytes from a healthy person was studied for the first time. By means of atomic force microscopy, it was found that C
60
FAS in a concentration of 0.1 mg/ml increases the stiffness of the lymphocyte membrane by 41 % (
p
< 0.05) and lowers the functional activity of the plasmalemma surface, thereby constraining the use of its membrane material in physiological reactions using a hypotonic model in vitro. However, a cell retains the ability to regulate its volume and demonstrates relative resistance to hypo-osmotic stress. The resistance of lymphocytes in hypo-osmotic medium is facilitated by activation of the nucleus by C
60
fullerene particles, which regulates the implementation of two consistent phases of an increase and decrease of cell volume, thereby retaining cell viability. All these indicate the impact of C
60
fullerene on the cellular nucleus.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26071689</pmid><doi>10.1007/s00249-015-1050-9</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics Letter Cell Biology Cells, Cultured Elasticity Fullerenes - pharmacology Humans Life Sciences Lymphocytes - drug effects Lymphocytes - physiology Membrane Biology Nanotechnology Neurobiology Osmoregulation |
| title | C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes |
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