Lamotrigine has no antiparkinsonian activity in rat models of Parkinson's disease

In rodent models of Parkinson's disease such as reserpinized or 6-hydroxydopamine substantia nigra lesioned rats, blockade of glutamate receptors of the NMDA ( N-methyl- d-aspartate) or the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) receptor subtypes and concomitant treatment with...

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Veröffentlicht in:	European journal of pharmacology 1995-09, Vol.284 (1), p.129-134
Hauptverfasser:	Löschmann, Peter-Andreas, Eblen, Frank, Wüllner, Ullrich, Wachtel, Helmut, Klockgether, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal model Animals Antiparkinson Agents - pharmacology Apomorphine - pharmacology Dose-Response Relationship, Drug Lamotrigine Male Motor Activity - drug effects Oxidopamine - toxicity Parkinson Disease - drug therapy Parkinson's disease Rats Rats, Wistar Reserpine - pharmacology Rotation Stereotyped Behavior - drug effects Substantia Nigra - physiology Sympatholytics - toxicity Triazines - pharmacology
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