Peroxynitrite Induces Tyrosine Nitration and Modulates Tyrosine Phosphorylation of Synaptic Proteins

: Peroxynitrite, the product of the radical‐radical reaction between nitric oxide and superoxide anion, is a potent oxidant involved in tissue damage in neurodegenerative disorders. We investigated the modifications induced by peroxynitrite in tyrosine residues of proteins from synaptosomes. Peroxyn...

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Veröffentlicht in:	Journal of neurochemistry 1999-08, Vol.73 (2), p.727-735
Hauptverfasser:	Stasi, A. M. Michela Di, Mallozzi, Cinzia, Macchia, Gianfranco, Petrucci, Tamara C., Minetti, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Medical sciences Neurology Nitric oxide Peroxynitrite pp60src Synaptophysin Synaptosomes Tyrosine nitration Tyrosine phosphorylation
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