Genetically determined aberrant down-regulation of FcγRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a multigenic disease associated with IgG hypergammaglobulinemia, IgG anti-nuclear antibodies and immune complex (IC)-type glomerulonephritis. In both human and murine SLE, one susceptibility allele has been mapped to the interval linked to the IgG Fc receptor II...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International immunology 1999-10, Vol.11 (10), p.1685-1691
Hauptverfasser:	Jiang, Yi, Hirose, Sachiko, Sanokawa-Akakura, Reiko, Abe, Masaaki, Mi, Xiaoyi, Li, Na, Miura, Yuko, Shirai, Jun, Zhang, Danqing, Hamano, Yoshitomo, Shirai, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	AFc receptors ANOVA analysis of variance autoimmunity chromosome 1 disease susceptibility allele FcγR IgG Fc receptor IC immune complex IgG Fc receptors microsatellite New Zealand mouse strains PNA peanut agglutinin promoter polymorphism QTL quantitative trait loci SLE systemic lupus erythematosus SRBC sheep red blood cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!