Transcriptomic Analysis Reveals Wound Healing of Morus alba Root Extract by Up-Regulating Keratin Filament and CXCL12/CXCR4 Signaling

Facilitation of the wound healing process is important because a prolonged wound site increases pain and the risk of infection. In oriental medicine, an extract of Morus alba root (MA) has usually been prescribed as traditional treatment for accelerating wound healing, and it has been proven to be s...

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Veröffentlicht in:	Phytotherapy research 2015-08, Vol.29 (8), p.1251-1258
Hauptverfasser:	Kim, Kang-Hoon, Chung, Won-Seok, Kim, Yoomi, Kim, Ki-Suk, Lee, In-Seung, Park, Ji Young, Jeong, Hyeon-Soo, Na, Yun-Cheol, Lee, Chang-Hun, Jang, Hyeung-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals C-X-C motif chemokine 12 (CXCL12) Cell Line Cell Proliferation - drug effects Chemokine CXCL12 - metabolism chemokine receptor 4 (CXCR4) In Vitro Techniques Keratinocytes - drug effects Keratinocytes - metabolism Keratins - metabolism Mice, Inbred ICR Morus - chemistry Morus alba root Plant Extracts - pharmacology Plant Roots - chemistry Primary Cell Culture Receptors, CXCR4 - metabolism RNA, Messenger - metabolism Signal Transduction Skin - cytology Skin - drug effects therapeutic treatment Transcriptome Up-Regulation Wound Healing - drug effects
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