SPECTRUS: A Dimensionality Reduction Approach for Identifying Dynamical Domains in Protein Complexes from Limited Structural Datasets

Identifying dynamical, quasi-rigid domains in proteins provides a powerful means for characterizing functionally oriented structural changes via a parsimonious set of degrees of freedom. In fact, the relative displacements of few dynamical domains usually suffice to rationalize the mechanics underpi...

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Veröffentlicht in:	Structure (London) 2015-08, Vol.23 (8), p.1516-1525
Hauptverfasser:	Ponzoni, Luca, Polles, Guido, Carnevale, Vincenzo, Micheletti, Cristian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Kinase - chemistry Capsid - chemistry Escherichia coli - chemistry Escherichia coli - enzymology Internet Ion Channels - chemistry Models, Molecular Multifactor Dimensionality Reduction - methods Protein Structure, Tertiary Software Thermodynamics Tobacco mosaic satellite virus - chemistry
Online-Zugang:	Volltext
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