Structure of shikimate kinase, an in vivo essential metabolic enzyme in the nosocomial pathogen Acinetobacter baumannii, in complex with shikimate

Acinetobacter baumannii is an opportunistic Gram‐negative pathogen that is an important cause of healthcare‐associated infections exhibiting high mortality rates. Clinical isolates of multidrug‐resistant (MDR) and extremely drug‐resistant (XDR) A. baumannii strains are increasingly being observed. C...

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Veröffentlicht in:	Acta Crystallogr. D 2015-08, Vol.71 (8), p.1736-1744
Hauptverfasser:	Sutton, Kristin A., Breen, Jennifer, MacDonald, Ulrike, Beanan, Janet M., Olson, Ruth, Russo, Thomas A., Schultz, L. Wayne, Umland, Timothy C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii Acinetobacter baumannii - chemistry Acinetobacter baumannii - enzymology Acinetobacter baumannii - growth & development Acinetobacter baumannii - metabolism Acinetobacter Infections - metabolism Acinetobacter Infections - microbiology Animals antibiotic target Crystallography, X-Ray enzyme kinetics essential gene Humans ligand-induced conformational change Models, Molecular multi-drug and extreme drug resistance Phosphotransferases (Alcohol Group Acceptor) - chemistry Phosphotransferases (Alcohol Group Acceptor) - metabolism Protein Conformation Rats shikimate kinase Shikimic Acid - metabolism Signal Transduction
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