Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats

Drug-drug interactions have become a serious problem in the clinic, since plant-based medicines are extensively used. The present study investigated the effects of Ziziphus jujuba fruit (ZJ) extract on the pharmacokinetics of phenacetin, a typical substrate of a cytochrome P450 enzyme CYP 1A2, in ra...

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Veröffentlicht in:	Chinese journal of natural medicines 2015-08, Vol.13 (8), p.588-594
Hauptverfasser:	JING, Xin-Yue, PENG, Yun-Ru, WANG, Xin-Min, DUAN, Jin-Ao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - metabolism Animals Area Under Curve CYP1A2 Cytochrome P-450 CYP1A2 Cytochromes - metabolism Fruit Hepatic microsomes Herb-Drug Interactions Liver - drug effects Male Microsomes, Liver Phenacetin Phenacetin - metabolism Phenacetin - pharmacokinetics Plant drug-drug interactions Plant Extracts - pharmacology Rats, Sprague-Dawley Ziziphus Ziziphus jujuba
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