Regulatory effect of chemokines in bone marrow niche
Chemokines secreted from different cellular components of bone marrow (BM) play an important role in the formation of the BM niche system. The hematopoietic stem cell (HSC) pool located in specialized anatomical sites within the BM is subjected to a complex network of chemokines, such that the produ...
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| Veröffentlicht in: | Cell and tissue research 2015-08, Vol.361 (2), p.401-410 |
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| creator | Ahmadzadeh, Ahmad Kast, Richard E Ketabchi, Neda Shahrabi, Saeid Shahjahani, Mohammad Jaseb, Kaveh Saki, Najmaldin |
| description | Chemokines secreted from different cellular components of bone marrow (BM) play an important role in the formation of the BM niche system. The hematopoietic stem cell (HSC) pool located in specialized anatomical sites within the BM is subjected to a complex network of chemokines, such that the produced chemokines affect the fate of these cells. Expression of different chemokine receptors on leukemic stem cells (LSCs) uncovers the critical role of chemokines in the maintenance, survival and fate of these cells in the leukemic niche. As a pre-metastatic niche rich in a variety of chemokines, the BM niche is turned into a locus of tumor cell development and division. The chemokine receptors expressed on the surface of metastatic cells lead to their metastasis and homing to the BM niche. Knowledge of chemokines and their receptors leads to the production of various therapeutic antagonists at chemokine receptors expressed on leukemic and tumor cells, enabling interference with chemokine function as a therapeutic tool. New findings suggest that miRNAs, with their specific inhibitory function, affect the ability of producing and expressing chemokines and chemokine receptors. This review focuses on the emerging role of chemokines and their receptors in normal and pathologic conditions of the BM niche, and also discusses the new therapeutic methods with this background. |
| doi_str_mv | 10.1007/s00441-015-2129-4 |
| format | Article |
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The hematopoietic stem cell (HSC) pool located in specialized anatomical sites within the BM is subjected to a complex network of chemokines, such that the produced chemokines affect the fate of these cells. Expression of different chemokine receptors on leukemic stem cells (LSCs) uncovers the critical role of chemokines in the maintenance, survival and fate of these cells in the leukemic niche. As a pre-metastatic niche rich in a variety of chemokines, the BM niche is turned into a locus of tumor cell development and division. The chemokine receptors expressed on the surface of metastatic cells lead to their metastasis and homing to the BM niche. Knowledge of chemokines and their receptors leads to the production of various therapeutic antagonists at chemokine receptors expressed on leukemic and tumor cells, enabling interference with chemokine function as a therapeutic tool. New findings suggest that miRNAs, with their specific inhibitory function, affect the ability of producing and expressing chemokines and chemokine receptors. This review focuses on the emerging role of chemokines and their receptors in normal and pathologic conditions of the BM niche, and also discusses the new therapeutic methods with this background.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-015-2129-4</identifier><identifier>PMID: 25715759</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; antagonists ; Biomedical and Life Sciences ; Biomedicine ; Bone marrow ; Bone Marrow - immunology ; Bone Marrow - metabolism ; Bone Marrow - pathology ; chemokine receptors ; Chemokines ; Chemokines - analysis ; Chemokines - genetics ; Chemokines - immunology ; Development and progression ; Gene Expression Regulation, Leukemic ; Hematopoietic stem cells ; Human Genetics ; Humans ; Leukemia ; Leukemia - genetics ; Leukemia - immunology ; Leukemia - pathology ; loci ; Metastasis ; microRNA ; MicroRNAs - genetics ; Molecular Medicine ; neoplasm cells ; Neoplasm Metastasis - genetics ; Neoplasm Metastasis - immunology ; Neoplasm Metastasis - pathology ; Neoplastic Stem Cells - immunology ; Neoplastic Stem Cells - metabolism ; Neoplastic Stem Cells - pathology ; Proteomics ; Review ; Stem Cell Niche ; Stem cells</subject><ispartof>Cell and tissue research, 2015-08, Vol.361 (2), p.401-410</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>COPYRIGHT 2015 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-3562a4165ec17ac4fbf369c69485ab1e6b56533b50ac7e6d172e5f32baed802e3</citedby><cites>FETCH-LOGICAL-c494t-3562a4165ec17ac4fbf369c69485ab1e6b56533b50ac7e6d172e5f32baed802e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-015-2129-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-015-2129-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>313,314,776,780,788,27901,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25715759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmadzadeh, Ahmad</creatorcontrib><creatorcontrib>Kast, Richard E</creatorcontrib><creatorcontrib>Ketabchi, Neda</creatorcontrib><creatorcontrib>Shahrabi, Saeid</creatorcontrib><creatorcontrib>Shahjahani, Mohammad</creatorcontrib><creatorcontrib>Jaseb, Kaveh</creatorcontrib><creatorcontrib>Saki, Najmaldin</creatorcontrib><title>Regulatory effect of chemokines in bone marrow niche</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>Chemokines secreted from different cellular components of bone marrow (BM) play an important role in the formation of the BM niche system. The hematopoietic stem cell (HSC) pool located in specialized anatomical sites within the BM is subjected to a complex network of chemokines, such that the produced chemokines affect the fate of these cells. Expression of different chemokine receptors on leukemic stem cells (LSCs) uncovers the critical role of chemokines in the maintenance, survival and fate of these cells in the leukemic niche. As a pre-metastatic niche rich in a variety of chemokines, the BM niche is turned into a locus of tumor cell development and division. The chemokine receptors expressed on the surface of metastatic cells lead to their metastasis and homing to the BM niche. Knowledge of chemokines and their receptors leads to the production of various therapeutic antagonists at chemokine receptors expressed on leukemic and tumor cells, enabling interference with chemokine function as a therapeutic tool. New findings suggest that miRNAs, with their specific inhibitory function, affect the ability of producing and expressing chemokines and chemokine receptors. This review focuses on the emerging role of chemokines and their receptors in normal and pathologic conditions of the BM niche, and also discusses the new therapeutic methods with this background.</description><subject>Animals</subject><subject>antagonists</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone marrow</subject><subject>Bone Marrow - immunology</subject><subject>Bone Marrow - metabolism</subject><subject>Bone Marrow - pathology</subject><subject>chemokine receptors</subject><subject>Chemokines</subject><subject>Chemokines - analysis</subject><subject>Chemokines - genetics</subject><subject>Chemokines - immunology</subject><subject>Development and progression</subject><subject>Gene Expression Regulation, Leukemic</subject><subject>Hematopoietic stem cells</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia - genetics</subject><subject>Leukemia - immunology</subject><subject>Leukemia - pathology</subject><subject>loci</subject><subject>Metastasis</subject><subject>microRNA</subject><subject>MicroRNAs - genetics</subject><subject>Molecular Medicine</subject><subject>neoplasm cells</subject><subject>Neoplasm Metastasis - genetics</subject><subject>Neoplasm Metastasis - immunology</subject><subject>Neoplasm Metastasis - pathology</subject><subject>Neoplastic Stem Cells - immunology</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Proteomics</subject><subject>Review</subject><subject>Stem Cell Niche</subject><subject>Stem cells</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kV9rFDEUxYModq1-AF90oCC-TL03_2bnsRRthYKgFnwLmezNburMpCYzSL-9WadqKyJ5COT-ziH3HMaeIxwjQPMmA0iJNaCqOfK2lg_YCqXgNayb9UO2AgG8brT-csCe5HwFgFLr9jE74KpB1ah2xeRH2s69nWK6qch7clMVfeV2NMSvYaRchbHq4kjVYFOK36sxlNlT9sjbPtOz2_uQXb57-_n0vL74cPb-9OSidrKVUy2U5laiVuSwsU76zgvdOt3KtbIdku6UVkJ0CqxrSG-w4aS84J2lzRo4iUP2evG9TvHbTHkyQ8iO-t6OFOdssAGulRIcC3r0F3oV5zSW3_2ksNUC1R9qa3syYfRxStbtTc2J5CUcaLku1PE_qHI2NARXwvChvN8TvLoj2JHtp12O_TyFOOb7IC6gSzHnRN5cp1CSvTEIZl-pWSo1pVKzr9TIonlxu9ncDbT5rfjVYQH4AuQyGreU7qz-H9eXi8jbaOw2hWwuP_ECAHCuJYL4AR5TsEc</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Ahmadzadeh, Ahmad</creator><creator>Kast, Richard E</creator><creator>Ketabchi, Neda</creator><creator>Shahrabi, Saeid</creator><creator>Shahjahani, Mohammad</creator><creator>Jaseb, Kaveh</creator><creator>Saki, Najmaldin</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>Regulatory effect of chemokines in bone marrow niche</title><author>Ahmadzadeh, Ahmad ; Kast, Richard E ; Ketabchi, Neda ; Shahrabi, Saeid ; Shahjahani, Mohammad ; Jaseb, Kaveh ; Saki, Najmaldin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-3562a4165ec17ac4fbf369c69485ab1e6b56533b50ac7e6d172e5f32baed802e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>antagonists</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone marrow</topic><topic>Bone Marrow - immunology</topic><topic>Bone Marrow - metabolism</topic><topic>Bone Marrow - pathology</topic><topic>chemokine receptors</topic><topic>Chemokines</topic><topic>Chemokines - analysis</topic><topic>Chemokines - genetics</topic><topic>Chemokines - immunology</topic><topic>Development and progression</topic><topic>Gene Expression Regulation, Leukemic</topic><topic>Hematopoietic stem cells</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia - genetics</topic><topic>Leukemia - immunology</topic><topic>Leukemia - pathology</topic><topic>loci</topic><topic>Metastasis</topic><topic>microRNA</topic><topic>MicroRNAs - genetics</topic><topic>Molecular Medicine</topic><topic>neoplasm cells</topic><topic>Neoplasm Metastasis - genetics</topic><topic>Neoplasm Metastasis - immunology</topic><topic>Neoplasm Metastasis - pathology</topic><topic>Neoplastic Stem Cells - immunology</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Neoplastic Stem Cells - 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Academic</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmadzadeh, Ahmad</au><au>Kast, Richard E</au><au>Ketabchi, Neda</au><au>Shahrabi, Saeid</au><au>Shahjahani, Mohammad</au><au>Jaseb, Kaveh</au><au>Saki, Najmaldin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulatory effect of chemokines in bone marrow niche</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>361</volume><issue>2</issue><spage>401</spage><epage>410</epage><pages>401-410</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>Chemokines secreted from different cellular components of bone marrow (BM) play an important role in the formation of the BM niche system. The hematopoietic stem cell (HSC) pool located in specialized anatomical sites within the BM is subjected to a complex network of chemokines, such that the produced chemokines affect the fate of these cells. Expression of different chemokine receptors on leukemic stem cells (LSCs) uncovers the critical role of chemokines in the maintenance, survival and fate of these cells in the leukemic niche. As a pre-metastatic niche rich in a variety of chemokines, the BM niche is turned into a locus of tumor cell development and division. The chemokine receptors expressed on the surface of metastatic cells lead to their metastasis and homing to the BM niche. Knowledge of chemokines and their receptors leads to the production of various therapeutic antagonists at chemokine receptors expressed on leukemic and tumor cells, enabling interference with chemokine function as a therapeutic tool. New findings suggest that miRNAs, with their specific inhibitory function, affect the ability of producing and expressing chemokines and chemokine receptors. This review focuses on the emerging role of chemokines and their receptors in normal and pathologic conditions of the BM niche, and also discusses the new therapeutic methods with this background.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25715759</pmid><doi>10.1007/s00441-015-2129-4</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals antagonists Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow - immunology Bone Marrow - metabolism Bone Marrow - pathology chemokine receptors Chemokines Chemokines - analysis Chemokines - genetics Chemokines - immunology Development and progression Gene Expression Regulation, Leukemic Hematopoietic stem cells Human Genetics Humans Leukemia Leukemia - genetics Leukemia - immunology Leukemia - pathology loci Metastasis microRNA MicroRNAs - genetics Molecular Medicine neoplasm cells Neoplasm Metastasis - genetics Neoplasm Metastasis - immunology Neoplasm Metastasis - pathology Neoplastic Stem Cells - immunology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Proteomics Review Stem Cell Niche Stem cells |
| title | Regulatory effect of chemokines in bone marrow niche |
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