BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice

Aims/hypothesis We explored the effects of β-aminoisobutyric acid (BAIBA) on hyperlipidaemic-condition-induced insulin resistance and inflammation as mediated through a signalling pathway involving AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor δ (PPARδ). Methods...

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Veröffentlicht in:	Diabetologia 2015-09, Vol.58 (9), p.2096-2105
Hauptverfasser:	Jung, Tae Woo, Hwang, Hwan-Jin, Hong, Ho Cheol, Yoo, Hye Jin, Baik, Sei Hyun, Choi, Kyung Mook
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Aminoisobutyric Acids - chemistry AMP-Activated Protein Kinases - metabolism Animals Carnitine O-Palmitoyltransferase - metabolism Diabetes Mellitus - metabolism Diet, High-Fat - adverse effects Fatty Acids - chemistry Gene Expression Regulation Glucose Tolerance Test Human Physiology Inflammation - physiopathology Insulin - metabolism Insulin Resistance Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Muscle Fibers, Skeletal - metabolism NF-kappa B - metabolism Oxygen - chemistry Palmitates - adverse effects Receptors, Cytoplasmic and Nuclear - metabolism RNA, Small Interfering - metabolism Signal Transduction
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