The evolutionary origins of Southeast Asian Ovalocytosis

•SAO is among the oldest human malaria-resistance alleles discovered to date.•Considerable haplotype variation exists among chromosomes bearing the SAO mutation.•Selection operating on SAO was historically much weaker than it is at present day.•SAO likely was the target of a partial “soft sweep”. So...

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Veröffentlicht in:	Infection, genetics and evolution genetics and evolution, 2015-08, Vol.34, p.153-159
Hauptverfasser:	Paquette, A.M., Harahap, A., Laosombat, V., Patnode, J.M., Satyagraha, A., Sudoyo, H., Thompson, M.K., Yusoff, N.M., Wilder, J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anion Exchange Protein 1, Erythrocyte - genetics Asia, Southeastern Elliptocytosis, Hereditary - genetics Evolution, Molecular Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Haplotypes Humans Linkage Disequilibrium Malaria Malaria - genetics Male Ovalocytosis Polymorphism, Single Nucleotide Selection, Genetic Sequence Analysis, DNA SLC4A1 Soft sweep
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