Biologically active compounds based on the privileged 2-imidazoline scaffold: The world beyond adrenergic/imidazoline receptor modulators

2-Imidazolines are well known as pharmacophores for various isoforms of adrenergic (α) and imidazoline (I) receptors. The biological activities exerted through the modulation of these targets, mostly in the central nervous system, have found utility in the development of many drug candidates – and e...

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Veröffentlicht in:	European journal of medicinal chemistry 2015-06, Vol.97, p.525-537
1. Verfasser:	Krasavin, Mikhail
Format:	Artikel
Sprache:	eng
Schlagworte:	2-imidazolines Animals Drug Discovery - methods Humans Imidazoles - chemistry Imidazoles - pharmacology Imidazoline Receptors - metabolism Molecular Targeted Therapy Phenotype Phenotypic biological activity Privileged structures Receptors, Adrenergic - metabolism Scaffolds Target-specific biological assays
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