Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas
Background “Skip” lymphovascular invasion presenting as discontinuous foci of tumor cells within the colon wall is now excluded from consideration when determining T stage in the TNM classification. The purpose of this study was to assess the clinicopathological characteristics of colorectal cancer...
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| Veröffentlicht in: | International journal of clinical oncology 2015-08, Vol.20 (4), p.761-766 |
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| container_title | International journal of clinical oncology |
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| creator | Okamoto, Yosuke Mitomi, Hiroyuki Ichikawa, Kazuhito Tomita, Shigeki Fujimori, Takahiro Igarashi, Yoshinori |
| description | Background
“Skip” lymphovascular invasion presenting as discontinuous foci of tumor cells within the colon wall is now excluded from consideration when determining T stage in the TNM classification. The purpose of this study was to assess the clinicopathological characteristics of colorectal cancer (CRC) patients with such skip lymphovascular invasion.
Methods
First, a retrospective questionnaire survey of the incidence of skip lymphovascular invasion was performed for a total of 1,868 patients with CRCs at ten institutions. Next, we comparatively assessed clinicopathological data for 896 CRC patients with or without skip lymphovascular invasion.
Results
The incidence of skip lymphovascular invasion was 1.1 % (20 out of 1,868). Most of the affected cases were rectal, pT2, and node negative, with moderately differentiated histology. Skip lymphovascular invasion was present in the muscularis propria and subserosa, with the tumors directly invading submucosa (pT1) or muscularis propria (pT2). Hepatic metastasis was greater in CRC with skip lymphovascular invasion (25 %) than in pT1/2 CRC (0 %;
P
|
| doi_str_mv | 10.1007/s10147-014-0778-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1702652751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3770742941</sourcerecordid><originalsourceid>FETCH-LOGICAL-c616t-98a969d5546369bd3bab7139c62e34a96805fa7ce901dcb77b10aa27a9bef9983</originalsourceid><addsrcrecordid>eNp1kF9LwzAUxYMoTqcfwBcp-OJLNWma3OZRxvwDA1_cc0jT1HW2TU1aYfv0ZnaKCMLl5sL53ZPkIHRB8A3BGG49wSSFOLQYA2Tx9gCdkJRCDADJYZhpSmLBEzZBp96vMSbAWXKMJglLM0oJO0HLeVka3Ue2jPxb1UX1pulW9kN5PdTKRVUbxsq2UaiV6VRf6agxvfKhKh_kSNvauuCg6kgrp6vWNsqfoaNS1d6c788pWt7PX2aP8eL54Wl2t4g1J7yPRaYEFwVjKadc5AXNVQ6ECs0TQ9OgZZiVCrQRmBQ6B8gJVioBJXJTCpHRKboefTtn3wfje9lUXpu6Vq2xg5cEcBJ-DIwE9OoPuraDa8PrvijMKHARKDJS2lnvnSll56pGuY0kWO4yl2PmMjS5y1xuw87l3nnIG1P8bHyHHIBkBHyQ2lfjfl39r-snfBuNGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1702053769</pqid></control><display><type>article</type><title>Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Okamoto, Yosuke ; Mitomi, Hiroyuki ; Ichikawa, Kazuhito ; Tomita, Shigeki ; Fujimori, Takahiro ; Igarashi, Yoshinori</creator><creatorcontrib>Okamoto, Yosuke ; Mitomi, Hiroyuki ; Ichikawa, Kazuhito ; Tomita, Shigeki ; Fujimori, Takahiro ; Igarashi, Yoshinori ; Study Group for Depth of Tumor Invasion projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR)</creatorcontrib><description>Background
“Skip” lymphovascular invasion presenting as discontinuous foci of tumor cells within the colon wall is now excluded from consideration when determining T stage in the TNM classification. The purpose of this study was to assess the clinicopathological characteristics of colorectal cancer (CRC) patients with such skip lymphovascular invasion.
Methods
First, a retrospective questionnaire survey of the incidence of skip lymphovascular invasion was performed for a total of 1,868 patients with CRCs at ten institutions. Next, we comparatively assessed clinicopathological data for 896 CRC patients with or without skip lymphovascular invasion.
Results
The incidence of skip lymphovascular invasion was 1.1 % (20 out of 1,868). Most of the affected cases were rectal, pT2, and node negative, with moderately differentiated histology. Skip lymphovascular invasion was present in the muscularis propria and subserosa, with the tumors directly invading submucosa (pT1) or muscularis propria (pT2). Hepatic metastasis was greater in CRC with skip lymphovascular invasion (25 %) than in pT1/2 CRC (0 %;
P
< 0.001) or pT3 CRC without such invasion (13.8 %;
P
= 0.185).
Conclusions
Our study suggests that skip lymphovascular invasion is associated with hepatic metastasis in CRC cases. Thus, definition of a T category including such invasion would be useful for clinical practice.</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-014-0778-z</identifier><identifier>PMID: 25483315</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adenocarcinoma - pathology ; Adenocarcinoma - secondary ; Adult ; Aged ; Aged, 80 and over ; Cancer Research ; Colorectal cancer ; Colorectal Neoplasms - pathology ; Female ; Humans ; Liver ; Liver Neoplasms - pathology ; Liver Neoplasms - secondary ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Lymphatic system ; Male ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Oncology ; Original Article ; Retrospective Studies ; Surgical Oncology ; Vascular Neoplasms - pathology ; Vascular Neoplasms - secondary ; Young Adult</subject><ispartof>International journal of clinical oncology, 2015-08, Vol.20 (4), p.761-766</ispartof><rights>Japan Society of Clinical Oncology 2014</rights><rights>Japan Society of Clinical Oncology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c616t-98a969d5546369bd3bab7139c62e34a96805fa7ce901dcb77b10aa27a9bef9983</citedby><cites>FETCH-LOGICAL-c616t-98a969d5546369bd3bab7139c62e34a96805fa7ce901dcb77b10aa27a9bef9983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10147-014-0778-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10147-014-0778-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27902,27903,41466,42535,51296</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25483315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okamoto, Yosuke</creatorcontrib><creatorcontrib>Mitomi, Hiroyuki</creatorcontrib><creatorcontrib>Ichikawa, Kazuhito</creatorcontrib><creatorcontrib>Tomita, Shigeki</creatorcontrib><creatorcontrib>Fujimori, Takahiro</creatorcontrib><creatorcontrib>Igarashi, Yoshinori</creatorcontrib><creatorcontrib>Study Group for Depth of Tumor Invasion projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR)</creatorcontrib><title>Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><addtitle>Int J Clin Oncol</addtitle><description>Background
“Skip” lymphovascular invasion presenting as discontinuous foci of tumor cells within the colon wall is now excluded from consideration when determining T stage in the TNM classification. The purpose of this study was to assess the clinicopathological characteristics of colorectal cancer (CRC) patients with such skip lymphovascular invasion.
Methods
First, a retrospective questionnaire survey of the incidence of skip lymphovascular invasion was performed for a total of 1,868 patients with CRCs at ten institutions. Next, we comparatively assessed clinicopathological data for 896 CRC patients with or without skip lymphovascular invasion.
Results
The incidence of skip lymphovascular invasion was 1.1 % (20 out of 1,868). Most of the affected cases were rectal, pT2, and node negative, with moderately differentiated histology. Skip lymphovascular invasion was present in the muscularis propria and subserosa, with the tumors directly invading submucosa (pT1) or muscularis propria (pT2). Hepatic metastasis was greater in CRC with skip lymphovascular invasion (25 %) than in pT1/2 CRC (0 %;
P
< 0.001) or pT3 CRC without such invasion (13.8 %;
P
= 0.185).
Conclusions
Our study suggests that skip lymphovascular invasion is associated with hepatic metastasis in CRC cases. Thus, definition of a T category including such invasion would be useful for clinical practice.</description><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - secondary</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer Research</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Retrospective Studies</subject><subject>Surgical Oncology</subject><subject>Vascular Neoplasms - pathology</subject><subject>Vascular Neoplasms - secondary</subject><subject>Young Adult</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kF9LwzAUxYMoTqcfwBcp-OJLNWma3OZRxvwDA1_cc0jT1HW2TU1aYfv0ZnaKCMLl5sL53ZPkIHRB8A3BGG49wSSFOLQYA2Tx9gCdkJRCDADJYZhpSmLBEzZBp96vMSbAWXKMJglLM0oJO0HLeVka3Ue2jPxb1UX1pulW9kN5PdTKRVUbxsq2UaiV6VRf6agxvfKhKh_kSNvauuCg6kgrp6vWNsqfoaNS1d6c788pWt7PX2aP8eL54Wl2t4g1J7yPRaYEFwVjKadc5AXNVQ6ECs0TQ9OgZZiVCrQRmBQ6B8gJVioBJXJTCpHRKboefTtn3wfje9lUXpu6Vq2xg5cEcBJ-DIwE9OoPuraDa8PrvijMKHARKDJS2lnvnSll56pGuY0kWO4yl2PmMjS5y1xuw87l3nnIG1P8bHyHHIBkBHyQ2lfjfl39r-snfBuNGA</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Okamoto, Yosuke</creator><creator>Mitomi, Hiroyuki</creator><creator>Ichikawa, Kazuhito</creator><creator>Tomita, Shigeki</creator><creator>Fujimori, Takahiro</creator><creator>Igarashi, Yoshinori</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas</title><author>Okamoto, Yosuke ; Mitomi, Hiroyuki ; Ichikawa, Kazuhito ; Tomita, Shigeki ; Fujimori, Takahiro ; Igarashi, Yoshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c616t-98a969d5546369bd3bab7139c62e34a96805fa7ce901dcb77b10aa27a9bef9983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - secondary</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer Research</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Retrospective Studies</topic><topic>Surgical Oncology</topic><topic>Vascular Neoplasms - pathology</topic><topic>Vascular Neoplasms - secondary</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okamoto, Yosuke</creatorcontrib><creatorcontrib>Mitomi, Hiroyuki</creatorcontrib><creatorcontrib>Ichikawa, Kazuhito</creatorcontrib><creatorcontrib>Tomita, Shigeki</creatorcontrib><creatorcontrib>Fujimori, Takahiro</creatorcontrib><creatorcontrib>Igarashi, Yoshinori</creatorcontrib><creatorcontrib>Study Group for Depth of Tumor Invasion projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okamoto, Yosuke</au><au>Mitomi, Hiroyuki</au><au>Ichikawa, Kazuhito</au><au>Tomita, Shigeki</au><au>Fujimori, Takahiro</au><au>Igarashi, Yoshinori</au><aucorp>Study Group for Depth of Tumor Invasion projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><addtitle>Int J Clin Oncol</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>20</volume><issue>4</issue><spage>761</spage><epage>766</epage><pages>761-766</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>Background
“Skip” lymphovascular invasion presenting as discontinuous foci of tumor cells within the colon wall is now excluded from consideration when determining T stage in the TNM classification. The purpose of this study was to assess the clinicopathological characteristics of colorectal cancer (CRC) patients with such skip lymphovascular invasion.
Methods
First, a retrospective questionnaire survey of the incidence of skip lymphovascular invasion was performed for a total of 1,868 patients with CRCs at ten institutions. Next, we comparatively assessed clinicopathological data for 896 CRC patients with or without skip lymphovascular invasion.
Results
The incidence of skip lymphovascular invasion was 1.1 % (20 out of 1,868). Most of the affected cases were rectal, pT2, and node negative, with moderately differentiated histology. Skip lymphovascular invasion was present in the muscularis propria and subserosa, with the tumors directly invading submucosa (pT1) or muscularis propria (pT2). Hepatic metastasis was greater in CRC with skip lymphovascular invasion (25 %) than in pT1/2 CRC (0 %;
P
< 0.001) or pT3 CRC without such invasion (13.8 %;
P
= 0.185).
Conclusions
Our study suggests that skip lymphovascular invasion is associated with hepatic metastasis in CRC cases. Thus, definition of a T category including such invasion would be useful for clinical practice.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>25483315</pmid><doi>10.1007/s10147-014-0778-z</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1341-9625 |
| ispartof | International journal of clinical oncology, 2015-08, Vol.20 (4), p.761-766 |
| issn | 1341-9625 1437-7772 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adenocarcinoma - pathology Adenocarcinoma - secondary Adult Aged Aged, 80 and over Cancer Research Colorectal cancer Colorectal Neoplasms - pathology Female Humans Liver Liver Neoplasms - pathology Liver Neoplasms - secondary Lymph Nodes - pathology Lymphatic Metastasis Lymphatic system Male Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Invasiveness Neoplasm Staging Oncology Original Article Retrospective Studies Surgical Oncology Vascular Neoplasms - pathology Vascular Neoplasms - secondary Young Adult |
| title | Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas |
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