Cerebrospinal Fluid CRH Levels in Late Pregnancy Are Not Associated With New-Onset Postpartum Depressive Symptoms
Context: CRH participates in the hypothalamic-pituitary-adrenal axis and in neural circuits involved in the pathophysiology of depression. During pregnancy, the placenta produces large amounts of CRH, and production ceases abruptly after delivery. The relationship between CRH in the cerebrospinal fl...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2015-08, Vol.100 (8), p.3159-3164 |
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| creator | Zaconeta, Alberto Moreno Amato, Angélica Amorim Barra, Gustavo Barcelos Casulari da Motta, Lucília Domingues de Souza, Vinícius Carolino Karnikowski, Margô Gomes de Oliveira Casulari, Luiz Augusto |
| description | Context:
CRH participates in the hypothalamic-pituitary-adrenal axis and in neural circuits involved in the pathophysiology of depression. During pregnancy, the placenta produces large amounts of CRH, and production ceases abruptly after delivery. The relationship between CRH in the cerebrospinal fluid (CSF) during pregnancy and peripartum mood disorders has not been investigated.
Objectives:
The objectives were to determine whether there are differences in CSF CRH concentrations of pregnant and nonpregnant women and whether CSF CRH concentrations in late pregnancy are associated with the presence of depressive symptoms during pregnancy and in the early postpartum period.
Design:
This was a prospective cohort study conducted from January to April, 2011.
Setting:
The study was conducted in one public and two private hospitals in Brasilia, Brazil.
Patients:
Patients included 107 healthy pregnant women who underwent elective cesarean delivery and 22 nonpregnant healthy women who underwent spinal anesthesia for elective surgical sterilization.
Intervention:
CRH in CSF was measured in pregnant and nonpregnant women by ELISA.
Main Outcome Measure:
The association between CSF CRH concentration at delivery and maternal depression assessed before cesarean section and postpartum (4 to 8 wk) with the Edinburgh Postnatal Depression Scale (EPDS), with a cutoff of ≥ 13.
Results:
CRH concentration in the CSF was significantly higher in pregnant (4.1 ± 0.51 log CRH) than in nonpregnant women (3.6 ± 0.26 log CRH) (P < .001). Depressive symptoms starting after delivery occurred in 5.6% of women. CRH concentration in CSF was not different between women without depressive symptoms and women showing such symptoms during pregnancy or in the postpartum period.
Conclusion:
CRH concentration in the CSF was higher in pregnant women than in nonpregnant women. However, in this sample, CSF CRH in late pregnancy was not associated with new-onset depressive symptoms in the early postpartum period. |
| doi_str_mv | 10.1210/jc.2014-4503 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1702652722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1702652722</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4185-81c7150467ca45976850305f00c836a91f6127d130a590cd1d24f932522d49613</originalsourceid><addsrcrecordid>eNptkc1vFCEYh4nR2LV682w4epAKDB8zx81qrcmmbfyI3ghl3nFnZYYpMN3sfy-bqZ7kQoDn_eV9HxB6zegF44y-37sLTpkgQtLqCVqxRkiiWaOfohWlnJFG859n6EVKe1owIavn6IwrqpTSfIXuNxDhLoY09aP1-NLPfYs3X67wFh7AJ9yPeGsz4NsIv0Y7uiNeR8DXIeN1SsH15a3FP_q8w9dwIDdjgoxvQ8qTjXke8AeYIqTUPwD-ehymHIb0Ej3rrE_w6nE_R98vP37bXJHtzafPm_WWOMFqSWrmNJNUKO2skI1WdZmPyo5SV1fKNqxTjOuWVdTKhrqWtVx0TcUl561oFKvO0dsld4rhfoaUzdAnB97bEcKcDNOUK8k15wV9t6CuiEgROjPFfrDxaBg1J8lm78xJsjlJLvibx-T5boD2H_zXagHEAhyCzxDTbz8fIJodWJ93hpZVxqpJSZS0LidyupGlrFrKYGyDi_24yDP7MMfyOen_3fwB8Q6WVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1702652722</pqid></control><display><type>article</type><title>Cerebrospinal Fluid CRH Levels in Late Pregnancy Are Not Associated With New-Onset Postpartum Depressive Symptoms</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Zaconeta, Alberto Moreno ; Amato, Angélica Amorim ; Barra, Gustavo Barcelos ; Casulari da Motta, Lucília Domingues ; de Souza, Vinícius Carolino ; Karnikowski, Margô Gomes de Oliveira ; Casulari, Luiz Augusto</creator><creatorcontrib>Zaconeta, Alberto Moreno ; Amato, Angélica Amorim ; Barra, Gustavo Barcelos ; Casulari da Motta, Lucília Domingues ; de Souza, Vinícius Carolino ; Karnikowski, Margô Gomes de Oliveira ; Casulari, Luiz Augusto</creatorcontrib><description>Context:
CRH participates in the hypothalamic-pituitary-adrenal axis and in neural circuits involved in the pathophysiology of depression. During pregnancy, the placenta produces large amounts of CRH, and production ceases abruptly after delivery. The relationship between CRH in the cerebrospinal fluid (CSF) during pregnancy and peripartum mood disorders has not been investigated.
Objectives:
The objectives were to determine whether there are differences in CSF CRH concentrations of pregnant and nonpregnant women and whether CSF CRH concentrations in late pregnancy are associated with the presence of depressive symptoms during pregnancy and in the early postpartum period.
Design:
This was a prospective cohort study conducted from January to April, 2011.
Setting:
The study was conducted in one public and two private hospitals in Brasilia, Brazil.
Patients:
Patients included 107 healthy pregnant women who underwent elective cesarean delivery and 22 nonpregnant healthy women who underwent spinal anesthesia for elective surgical sterilization.
Intervention:
CRH in CSF was measured in pregnant and nonpregnant women by ELISA.
Main Outcome Measure:
The association between CSF CRH concentration at delivery and maternal depression assessed before cesarean section and postpartum (4 to 8 wk) with the Edinburgh Postnatal Depression Scale (EPDS), with a cutoff of ≥ 13.
Results:
CRH concentration in the CSF was significantly higher in pregnant (4.1 ± 0.51 log CRH) than in nonpregnant women (3.6 ± 0.26 log CRH) (P < .001). Depressive symptoms starting after delivery occurred in 5.6% of women. CRH concentration in CSF was not different between women without depressive symptoms and women showing such symptoms during pregnancy or in the postpartum period.
Conclusion:
CRH concentration in the CSF was higher in pregnant women than in nonpregnant women. However, in this sample, CSF CRH in late pregnancy was not associated with new-onset depressive symptoms in the early postpartum period.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2014-4503</identifier><identifier>PMID: 26066672</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Adult ; Brazil - epidemiology ; Case-Control Studies ; Cohort Studies ; Corticotropin-Releasing Hormone - cerebrospinal fluid ; Depression - cerebrospinal fluid ; Depression - epidemiology ; Depression, Postpartum - cerebrospinal fluid ; Depression, Postpartum - epidemiology ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications - cerebrospinal fluid ; Pregnancy Complications - epidemiology ; Pregnancy Trimester, Third - cerebrospinal fluid ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2015-08, Vol.100 (8), p.3159-3164</ispartof><rights>Copyright © 2015 by the Endocrine Society</rights><rights>Copyright © 2015 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4185-81c7150467ca45976850305f00c836a91f6127d130a590cd1d24f932522d49613</citedby><cites>FETCH-LOGICAL-c4185-81c7150467ca45976850305f00c836a91f6127d130a590cd1d24f932522d49613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26066672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaconeta, Alberto Moreno</creatorcontrib><creatorcontrib>Amato, Angélica Amorim</creatorcontrib><creatorcontrib>Barra, Gustavo Barcelos</creatorcontrib><creatorcontrib>Casulari da Motta, Lucília Domingues</creatorcontrib><creatorcontrib>de Souza, Vinícius Carolino</creatorcontrib><creatorcontrib>Karnikowski, Margô Gomes de Oliveira</creatorcontrib><creatorcontrib>Casulari, Luiz Augusto</creatorcontrib><title>Cerebrospinal Fluid CRH Levels in Late Pregnancy Are Not Associated With New-Onset Postpartum Depressive Symptoms</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
CRH participates in the hypothalamic-pituitary-adrenal axis and in neural circuits involved in the pathophysiology of depression. During pregnancy, the placenta produces large amounts of CRH, and production ceases abruptly after delivery. The relationship between CRH in the cerebrospinal fluid (CSF) during pregnancy and peripartum mood disorders has not been investigated.
Objectives:
The objectives were to determine whether there are differences in CSF CRH concentrations of pregnant and nonpregnant women and whether CSF CRH concentrations in late pregnancy are associated with the presence of depressive symptoms during pregnancy and in the early postpartum period.
Design:
This was a prospective cohort study conducted from January to April, 2011.
Setting:
The study was conducted in one public and two private hospitals in Brasilia, Brazil.
Patients:
Patients included 107 healthy pregnant women who underwent elective cesarean delivery and 22 nonpregnant healthy women who underwent spinal anesthesia for elective surgical sterilization.
Intervention:
CRH in CSF was measured in pregnant and nonpregnant women by ELISA.
Main Outcome Measure:
The association between CSF CRH concentration at delivery and maternal depression assessed before cesarean section and postpartum (4 to 8 wk) with the Edinburgh Postnatal Depression Scale (EPDS), with a cutoff of ≥ 13.
Results:
CRH concentration in the CSF was significantly higher in pregnant (4.1 ± 0.51 log CRH) than in nonpregnant women (3.6 ± 0.26 log CRH) (P < .001). Depressive symptoms starting after delivery occurred in 5.6% of women. CRH concentration in CSF was not different between women without depressive symptoms and women showing such symptoms during pregnancy or in the postpartum period.
Conclusion:
CRH concentration in the CSF was higher in pregnant women than in nonpregnant women. However, in this sample, CSF CRH in late pregnancy was not associated with new-onset depressive symptoms in the early postpartum period.</description><subject>Adult</subject><subject>Brazil - epidemiology</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Corticotropin-Releasing Hormone - cerebrospinal fluid</subject><subject>Depression - cerebrospinal fluid</subject><subject>Depression - epidemiology</subject><subject>Depression, Postpartum - cerebrospinal fluid</subject><subject>Depression, Postpartum - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - cerebrospinal fluid</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Trimester, Third - cerebrospinal fluid</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1vFCEYh4nR2LV682w4epAKDB8zx81qrcmmbfyI3ghl3nFnZYYpMN3sfy-bqZ7kQoDn_eV9HxB6zegF44y-37sLTpkgQtLqCVqxRkiiWaOfohWlnJFG859n6EVKe1owIavn6IwrqpTSfIXuNxDhLoY09aP1-NLPfYs3X67wFh7AJ9yPeGsz4NsIv0Y7uiNeR8DXIeN1SsH15a3FP_q8w9dwIDdjgoxvQ8qTjXke8AeYIqTUPwD-ehymHIb0Ej3rrE_w6nE_R98vP37bXJHtzafPm_WWOMFqSWrmNJNUKO2skI1WdZmPyo5SV1fKNqxTjOuWVdTKhrqWtVx0TcUl561oFKvO0dsld4rhfoaUzdAnB97bEcKcDNOUK8k15wV9t6CuiEgROjPFfrDxaBg1J8lm78xJsjlJLvibx-T5boD2H_zXagHEAhyCzxDTbz8fIJodWJ93hpZVxqpJSZS0LidyupGlrFrKYGyDi_24yDP7MMfyOen_3fwB8Q6WVg</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Zaconeta, Alberto Moreno</creator><creator>Amato, Angélica Amorim</creator><creator>Barra, Gustavo Barcelos</creator><creator>Casulari da Motta, Lucília Domingues</creator><creator>de Souza, Vinícius Carolino</creator><creator>Karnikowski, Margô Gomes de Oliveira</creator><creator>Casulari, Luiz Augusto</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Cerebrospinal Fluid CRH Levels in Late Pregnancy Are Not Associated With New-Onset Postpartum Depressive Symptoms</title><author>Zaconeta, Alberto Moreno ; Amato, Angélica Amorim ; Barra, Gustavo Barcelos ; Casulari da Motta, Lucília Domingues ; de Souza, Vinícius Carolino ; Karnikowski, Margô Gomes de Oliveira ; Casulari, Luiz Augusto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4185-81c7150467ca45976850305f00c836a91f6127d130a590cd1d24f932522d49613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Brazil - epidemiology</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Corticotropin-Releasing Hormone - cerebrospinal fluid</topic><topic>Depression - cerebrospinal fluid</topic><topic>Depression - epidemiology</topic><topic>Depression, Postpartum - cerebrospinal fluid</topic><topic>Depression, Postpartum - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - cerebrospinal fluid</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy Trimester, Third - cerebrospinal fluid</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaconeta, Alberto Moreno</creatorcontrib><creatorcontrib>Amato, Angélica Amorim</creatorcontrib><creatorcontrib>Barra, Gustavo Barcelos</creatorcontrib><creatorcontrib>Casulari da Motta, Lucília Domingues</creatorcontrib><creatorcontrib>de Souza, Vinícius Carolino</creatorcontrib><creatorcontrib>Karnikowski, Margô Gomes de Oliveira</creatorcontrib><creatorcontrib>Casulari, Luiz Augusto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaconeta, Alberto Moreno</au><au>Amato, Angélica Amorim</au><au>Barra, Gustavo Barcelos</au><au>Casulari da Motta, Lucília Domingues</au><au>de Souza, Vinícius Carolino</au><au>Karnikowski, Margô Gomes de Oliveira</au><au>Casulari, Luiz Augusto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal Fluid CRH Levels in Late Pregnancy Are Not Associated With New-Onset Postpartum Depressive Symptoms</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2015-08</date><risdate>2015</risdate><volume>100</volume><issue>8</issue><spage>3159</spage><epage>3164</epage><pages>3159-3164</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context:
CRH participates in the hypothalamic-pituitary-adrenal axis and in neural circuits involved in the pathophysiology of depression. During pregnancy, the placenta produces large amounts of CRH, and production ceases abruptly after delivery. The relationship between CRH in the cerebrospinal fluid (CSF) during pregnancy and peripartum mood disorders has not been investigated.
Objectives:
The objectives were to determine whether there are differences in CSF CRH concentrations of pregnant and nonpregnant women and whether CSF CRH concentrations in late pregnancy are associated with the presence of depressive symptoms during pregnancy and in the early postpartum period.
Design:
This was a prospective cohort study conducted from January to April, 2011.
Setting:
The study was conducted in one public and two private hospitals in Brasilia, Brazil.
Patients:
Patients included 107 healthy pregnant women who underwent elective cesarean delivery and 22 nonpregnant healthy women who underwent spinal anesthesia for elective surgical sterilization.
Intervention:
CRH in CSF was measured in pregnant and nonpregnant women by ELISA.
Main Outcome Measure:
The association between CSF CRH concentration at delivery and maternal depression assessed before cesarean section and postpartum (4 to 8 wk) with the Edinburgh Postnatal Depression Scale (EPDS), with a cutoff of ≥ 13.
Results:
CRH concentration in the CSF was significantly higher in pregnant (4.1 ± 0.51 log CRH) than in nonpregnant women (3.6 ± 0.26 log CRH) (P < .001). Depressive symptoms starting after delivery occurred in 5.6% of women. CRH concentration in CSF was not different between women without depressive symptoms and women showing such symptoms during pregnancy or in the postpartum period.
Conclusion:
CRH concentration in the CSF was higher in pregnant women than in nonpregnant women. However, in this sample, CSF CRH in late pregnancy was not associated with new-onset depressive symptoms in the early postpartum period.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>26066672</pmid><doi>10.1210/jc.2014-4503</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2015-08, Vol.100 (8), p.3159-3164 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1702652722 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Brazil - epidemiology Case-Control Studies Cohort Studies Corticotropin-Releasing Hormone - cerebrospinal fluid Depression - cerebrospinal fluid Depression - epidemiology Depression, Postpartum - cerebrospinal fluid Depression, Postpartum - epidemiology Female Humans Infant, Newborn Pregnancy Pregnancy Complications - cerebrospinal fluid Pregnancy Complications - epidemiology Pregnancy Trimester, Third - cerebrospinal fluid Young Adult |
| title | Cerebrospinal Fluid CRH Levels in Late Pregnancy Are Not Associated With New-Onset Postpartum Depressive Symptoms |
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