Significantly inhibitory effects of low molecular weight heparin (Fraxiparine) on the motility of lung cancer cells and its related mechanism

Low molecular weight heparin (LMWH) improving the cancer survival has been attracting attention for many years. Our previous study found that LMWH (Fraxiparine) strongly downregulated the invasive, migratory, and adhesive ability of human lung adenocarcinoma A549 cells. Here, we aimed to further ide...

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Veröffentlicht in:	Tumor biology 2015-06, Vol.36 (6), p.4689-4697
Hauptverfasser:	Zhong, Guo-xing, Gong, Yi, Yu, Chuan-jiang, Wu, Shi-fei, Ma, Qing-ping, Wang, Yu, Ren, Jiang, Zhang, Xue-chao, Yang, Wei-han, Zhu, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - drug effects Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell adhesion & migration Cell Adhesion - drug effects Cell Movement - drug effects Chemokine CXCL12 - biosynthesis Chemokine CXCL12 - genetics Cytoskeleton Gene Expression Regulation, Neoplastic - drug effects Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Mice Molecular weight Motility Nadroparin - administration & dosage Neoplasm Invasiveness - genetics Phosphatidylinositol 3-Kinases - genetics Phosphorylation Proto-Oncogene Proteins c-akt - genetics Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - genetics Research Article Signal Transduction - drug effects TOR Serine-Threonine Kinases - genetics Xenograft Model Antitumor Assays
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