Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women
Purpose The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its rel...
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Veröffentlicht in: | Journal of endocrinological investigation 2015-03, Vol.38 (3), p.361-366 |
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creator | Akyildiz, Z. I. Polat, S. Yurekli, B. S. Kocabas, G. U. Tuluce, K. Tuluce, S. Y. Kocabas, U. Bozkaya, G. Yuksel, A. Nazli, C. |
description | Purpose
The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles.
Methods
Forty-five obese premenopausal women with body mass index (BMI) ≥30 kg/m
2
and 41 control premenopausal women with BMI |
doi_str_mv | 10.1007/s40618-014-0185-3 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1702652247</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1702652247</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-8fb2177afa4dfec04c469cfa083ee6cc49b9d76846c2c0af1b572ba40ee06a63</originalsourceid><addsrcrecordid>eNp9kctOHDEQRa0oKLzyAdlEXmZBg19je5YR4iUhsWFv2e7ypFF3u-PqhsyP8L2YDERZsfCjdG8duXwJ-cbZKWfMnKFimtuGcVWXXTXyEzngRrDGSqs__3ffJ4eID4xJI635QvbFSnJhpT4gzxdTF31pO9_T5OcTGnK7pYNHpN3Ywp8T6seWzqXb9NsIpWuB-gJ_tQnqNs405rHqYZlzQZoTRSjLQFMXSg69x5luSn6af1V8rBYqOO3hEfrKoDkAAp0KDDDmyS9YX_GUa3FM9pLvEb6-nUfk_vLi_vy6ub27ujn_edtEqdTc2BQEN8Ynr9oEkamo9Domz6wE0DGqdVi3Rlulo4jMJx5WRgSvGADTXssj8mOHnUr-vQDObugwQt_7EfKCjhsm9EoIZaqV76yxZMQCyU2lG3zZOs7caxpul4arabjXNJysPd_f8EsYoP3X8f791SB2BqzSuIHiHvJSxjrxB9QXz-eYyw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1702652247</pqid></control><display><type>article</type><title>Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Akyildiz, Z. I. ; Polat, S. ; Yurekli, B. S. ; Kocabas, G. U. ; Tuluce, K. ; Tuluce, S. Y. ; Kocabas, U. ; Bozkaya, G. ; Yuksel, A. ; Nazli, C.</creator><creatorcontrib>Akyildiz, Z. I. ; Polat, S. ; Yurekli, B. S. ; Kocabas, G. U. ; Tuluce, K. ; Tuluce, S. Y. ; Kocabas, U. ; Bozkaya, G. ; Yuksel, A. ; Nazli, C.</creatorcontrib><description>Purpose
The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles.
Methods
Forty-five obese premenopausal women with body mass index (BMI) ≥30 kg/m
2
and 41 control premenopausal women with BMI <25 kg/m
2
with similar SCORE project risk profiles were included in this case–control study. EFT was evaluated by two-dimensional transthoracic echocardiography. Serum FGF-21 was measured with an ELISA kit.
Results
FGF-21 and EFT were significantly higher in obese women compared to controls (
p
< 0.001). Multiple stepwise linear regression analysis showed that EFT, BMI, and triglycerides (TG) independently contributed to FGF-21 (
R
2
= 0.757,
p
< 0.001). However, homeostasis model assessment of insulin resistance (HOMA-IR), visceral ectopic fat, and inflammatory markers were not found as a direct contributor to serum FGF-21 level (
p
> 0.05).
Conclusions
EFT, BMI, and TG may play an important role in predicting serum FGF-21 level which may be a potential therapeutic target in cardiometabolic disorders in the future.</description><identifier>ISSN: 1720-8386</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-014-0185-3</identifier><identifier>PMID: 25312836</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Body Mass Index ; Case-Control Studies ; Endocrinology ; Female ; Fibroblast Growth Factors - blood ; Humans ; Insulin Resistance - physiology ; Intra-Abdominal Fat - metabolism ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity - blood ; Obesity - metabolism ; Original Article ; Pericardium ; Premenopause ; Triglycerides - blood</subject><ispartof>Journal of endocrinological investigation, 2015-03, Vol.38 (3), p.361-366</ispartof><rights>Italian Society of Endocrinology (SIE) 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-8fb2177afa4dfec04c469cfa083ee6cc49b9d76846c2c0af1b572ba40ee06a63</citedby><cites>FETCH-LOGICAL-c344t-8fb2177afa4dfec04c469cfa083ee6cc49b9d76846c2c0af1b572ba40ee06a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-014-0185-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-014-0185-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25312836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akyildiz, Z. I.</creatorcontrib><creatorcontrib>Polat, S.</creatorcontrib><creatorcontrib>Yurekli, B. S.</creatorcontrib><creatorcontrib>Kocabas, G. U.</creatorcontrib><creatorcontrib>Tuluce, K.</creatorcontrib><creatorcontrib>Tuluce, S. Y.</creatorcontrib><creatorcontrib>Kocabas, U.</creatorcontrib><creatorcontrib>Bozkaya, G.</creatorcontrib><creatorcontrib>Yuksel, A.</creatorcontrib><creatorcontrib>Nazli, C.</creatorcontrib><title>Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles.
Methods
Forty-five obese premenopausal women with body mass index (BMI) ≥30 kg/m
2
and 41 control premenopausal women with BMI <25 kg/m
2
with similar SCORE project risk profiles were included in this case–control study. EFT was evaluated by two-dimensional transthoracic echocardiography. Serum FGF-21 was measured with an ELISA kit.
Results
FGF-21 and EFT were significantly higher in obese women compared to controls (
p
< 0.001). Multiple stepwise linear regression analysis showed that EFT, BMI, and triglycerides (TG) independently contributed to FGF-21 (
R
2
= 0.757,
p
< 0.001). However, homeostasis model assessment of insulin resistance (HOMA-IR), visceral ectopic fat, and inflammatory markers were not found as a direct contributor to serum FGF-21 level (
p
> 0.05).
Conclusions
EFT, BMI, and TG may play an important role in predicting serum FGF-21 level which may be a potential therapeutic target in cardiometabolic disorders in the future.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fibroblast Growth Factors - blood</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Intra-Abdominal Fat - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity - blood</subject><subject>Obesity - metabolism</subject><subject>Original Article</subject><subject>Pericardium</subject><subject>Premenopause</subject><subject>Triglycerides - blood</subject><issn>1720-8386</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOHDEQRa0oKLzyAdlEXmZBg19je5YR4iUhsWFv2e7ypFF3u-PqhsyP8L2YDERZsfCjdG8duXwJ-cbZKWfMnKFimtuGcVWXXTXyEzngRrDGSqs__3ffJ4eID4xJI635QvbFSnJhpT4gzxdTF31pO9_T5OcTGnK7pYNHpN3Ywp8T6seWzqXb9NsIpWuB-gJ_tQnqNs405rHqYZlzQZoTRSjLQFMXSg69x5luSn6af1V8rBYqOO3hEfrKoDkAAp0KDDDmyS9YX_GUa3FM9pLvEb6-nUfk_vLi_vy6ub27ujn_edtEqdTc2BQEN8Ynr9oEkamo9Domz6wE0DGqdVi3Rlulo4jMJx5WRgSvGADTXssj8mOHnUr-vQDObugwQt_7EfKCjhsm9EoIZaqV76yxZMQCyU2lG3zZOs7caxpul4arabjXNJysPd_f8EsYoP3X8f791SB2BqzSuIHiHvJSxjrxB9QXz-eYyw</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Akyildiz, Z. I.</creator><creator>Polat, S.</creator><creator>Yurekli, B. S.</creator><creator>Kocabas, G. U.</creator><creator>Tuluce, K.</creator><creator>Tuluce, S. Y.</creator><creator>Kocabas, U.</creator><creator>Bozkaya, G.</creator><creator>Yuksel, A.</creator><creator>Nazli, C.</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women</title><author>Akyildiz, Z. I. ; Polat, S. ; Yurekli, B. S. ; Kocabas, G. U. ; Tuluce, K. ; Tuluce, S. Y. ; Kocabas, U. ; Bozkaya, G. ; Yuksel, A. ; Nazli, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-8fb2177afa4dfec04c469cfa083ee6cc49b9d76846c2c0af1b572ba40ee06a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fibroblast Growth Factors - blood</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Intra-Abdominal Fat - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Obesity - blood</topic><topic>Obesity - metabolism</topic><topic>Original Article</topic><topic>Pericardium</topic><topic>Premenopause</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akyildiz, Z. I.</creatorcontrib><creatorcontrib>Polat, S.</creatorcontrib><creatorcontrib>Yurekli, B. S.</creatorcontrib><creatorcontrib>Kocabas, G. U.</creatorcontrib><creatorcontrib>Tuluce, K.</creatorcontrib><creatorcontrib>Tuluce, S. Y.</creatorcontrib><creatorcontrib>Kocabas, U.</creatorcontrib><creatorcontrib>Bozkaya, G.</creatorcontrib><creatorcontrib>Yuksel, A.</creatorcontrib><creatorcontrib>Nazli, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akyildiz, Z. I.</au><au>Polat, S.</au><au>Yurekli, B. S.</au><au>Kocabas, G. U.</au><au>Tuluce, K.</au><au>Tuluce, S. Y.</au><au>Kocabas, U.</au><au>Bozkaya, G.</au><au>Yuksel, A.</au><au>Nazli, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>38</volume><issue>3</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>1720-8386</issn><eissn>1720-8386</eissn><abstract>Purpose
The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles.
Methods
Forty-five obese premenopausal women with body mass index (BMI) ≥30 kg/m
2
and 41 control premenopausal women with BMI <25 kg/m
2
with similar SCORE project risk profiles were included in this case–control study. EFT was evaluated by two-dimensional transthoracic echocardiography. Serum FGF-21 was measured with an ELISA kit.
Results
FGF-21 and EFT were significantly higher in obese women compared to controls (
p
< 0.001). Multiple stepwise linear regression analysis showed that EFT, BMI, and triglycerides (TG) independently contributed to FGF-21 (
R
2
= 0.757,
p
< 0.001). However, homeostasis model assessment of insulin resistance (HOMA-IR), visceral ectopic fat, and inflammatory markers were not found as a direct contributor to serum FGF-21 level (
p
> 0.05).
Conclusions
EFT, BMI, and TG may play an important role in predicting serum FGF-21 level which may be a potential therapeutic target in cardiometabolic disorders in the future.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>25312836</pmid><doi>10.1007/s40618-014-0185-3</doi><tpages>6</tpages></addata></record> |
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source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Adult Body Mass Index Case-Control Studies Endocrinology Female Fibroblast Growth Factors - blood Humans Insulin Resistance - physiology Intra-Abdominal Fat - metabolism Medicine Medicine & Public Health Metabolic Diseases Obesity - blood Obesity - metabolism Original Article Pericardium Premenopause Triglycerides - blood |
title | Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women |
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