Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women

Purpose The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its rel...

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Veröffentlicht in:Journal of endocrinological investigation 2015-03, Vol.38 (3), p.361-366
Hauptverfasser: Akyildiz, Z. I., Polat, S., Yurekli, B. S., Kocabas, G. U., Tuluce, K., Tuluce, S. Y., Kocabas, U., Bozkaya, G., Yuksel, A., Nazli, C.
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container_issue 3
container_start_page 361
container_title Journal of endocrinological investigation
container_volume 38
creator Akyildiz, Z. I.
Polat, S.
Yurekli, B. S.
Kocabas, G. U.
Tuluce, K.
Tuluce, S. Y.
Kocabas, U.
Bozkaya, G.
Yuksel, A.
Nazli, C.
description Purpose The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles. Methods Forty-five obese premenopausal women with body mass index (BMI) ≥30 kg/m 2 and 41 control premenopausal women with BMI
doi_str_mv 10.1007/s40618-014-0185-3
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I. ; Polat, S. ; Yurekli, B. S. ; Kocabas, G. U. ; Tuluce, K. ; Tuluce, S. Y. ; Kocabas, U. ; Bozkaya, G. ; Yuksel, A. ; Nazli, C.</creator><creatorcontrib>Akyildiz, Z. I. ; Polat, S. ; Yurekli, B. S. ; Kocabas, G. U. ; Tuluce, K. ; Tuluce, S. Y. ; Kocabas, U. ; Bozkaya, G. ; Yuksel, A. ; Nazli, C.</creatorcontrib><description>Purpose The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles. Methods Forty-five obese premenopausal women with body mass index (BMI) ≥30 kg/m 2 and 41 control premenopausal women with BMI &lt;25 kg/m 2 with similar SCORE project risk profiles were included in this case–control study. EFT was evaluated by two-dimensional transthoracic echocardiography. Serum FGF-21 was measured with an ELISA kit. Results FGF-21 and EFT were significantly higher in obese women compared to controls ( p  &lt; 0.001). Multiple stepwise linear regression analysis showed that EFT, BMI, and triglycerides (TG) independently contributed to FGF-21 ( R 2  = 0.757, p  &lt; 0.001). However, homeostasis model assessment of insulin resistance (HOMA-IR), visceral ectopic fat, and inflammatory markers were not found as a direct contributor to serum FGF-21 level ( p  &gt; 0.05). Conclusions EFT, BMI, and TG may play an important role in predicting serum FGF-21 level which may be a potential therapeutic target in cardiometabolic disorders in the future.</description><identifier>ISSN: 1720-8386</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-014-0185-3</identifier><identifier>PMID: 25312836</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Body Mass Index ; Case-Control Studies ; Endocrinology ; Female ; Fibroblast Growth Factors - blood ; Humans ; Insulin Resistance - physiology ; Intra-Abdominal Fat - metabolism ; Medicine ; Medicine &amp; Public Health ; Metabolic Diseases ; Obesity - blood ; Obesity - metabolism ; Original Article ; Pericardium ; Premenopause ; Triglycerides - blood</subject><ispartof>Journal of endocrinological investigation, 2015-03, Vol.38 (3), p.361-366</ispartof><rights>Italian Society of Endocrinology (SIE) 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-8fb2177afa4dfec04c469cfa083ee6cc49b9d76846c2c0af1b572ba40ee06a63</citedby><cites>FETCH-LOGICAL-c344t-8fb2177afa4dfec04c469cfa083ee6cc49b9d76846c2c0af1b572ba40ee06a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-014-0185-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-014-0185-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25312836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akyildiz, Z. I.</creatorcontrib><creatorcontrib>Polat, S.</creatorcontrib><creatorcontrib>Yurekli, B. S.</creatorcontrib><creatorcontrib>Kocabas, G. U.</creatorcontrib><creatorcontrib>Tuluce, K.</creatorcontrib><creatorcontrib>Tuluce, S. Y.</creatorcontrib><creatorcontrib>Kocabas, U.</creatorcontrib><creatorcontrib>Bozkaya, G.</creatorcontrib><creatorcontrib>Yuksel, A.</creatorcontrib><creatorcontrib>Nazli, C.</creatorcontrib><title>Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles. Methods Forty-five obese premenopausal women with body mass index (BMI) ≥30 kg/m 2 and 41 control premenopausal women with BMI &lt;25 kg/m 2 with similar SCORE project risk profiles were included in this case–control study. EFT was evaluated by two-dimensional transthoracic echocardiography. Serum FGF-21 was measured with an ELISA kit. Results FGF-21 and EFT were significantly higher in obese women compared to controls ( p  &lt; 0.001). Multiple stepwise linear regression analysis showed that EFT, BMI, and triglycerides (TG) independently contributed to FGF-21 ( R 2  = 0.757, p  &lt; 0.001). However, homeostasis model assessment of insulin resistance (HOMA-IR), visceral ectopic fat, and inflammatory markers were not found as a direct contributor to serum FGF-21 level ( p  &gt; 0.05). Conclusions EFT, BMI, and TG may play an important role in predicting serum FGF-21 level which may be a potential therapeutic target in cardiometabolic disorders in the future.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fibroblast Growth Factors - blood</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Intra-Abdominal Fat - metabolism</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity - blood</subject><subject>Obesity - metabolism</subject><subject>Original Article</subject><subject>Pericardium</subject><subject>Premenopause</subject><subject>Triglycerides - blood</subject><issn>1720-8386</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOHDEQRa0oKLzyAdlEXmZBg19je5YR4iUhsWFv2e7ypFF3u-PqhsyP8L2YDERZsfCjdG8duXwJ-cbZKWfMnKFimtuGcVWXXTXyEzngRrDGSqs__3ffJ4eID4xJI635QvbFSnJhpT4gzxdTF31pO9_T5OcTGnK7pYNHpN3Ywp8T6seWzqXb9NsIpWuB-gJ_tQnqNs405rHqYZlzQZoTRSjLQFMXSg69x5luSn6af1V8rBYqOO3hEfrKoDkAAp0KDDDmyS9YX_GUa3FM9pLvEb6-nUfk_vLi_vy6ub27ujn_edtEqdTc2BQEN8Ynr9oEkamo9Domz6wE0DGqdVi3Rlulo4jMJx5WRgSvGADTXssj8mOHnUr-vQDObugwQt_7EfKCjhsm9EoIZaqV76yxZMQCyU2lG3zZOs7caxpul4arabjXNJysPd_f8EsYoP3X8f791SB2BqzSuIHiHvJSxjrxB9QXz-eYyw</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Akyildiz, Z. 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I.</creatorcontrib><creatorcontrib>Polat, S.</creatorcontrib><creatorcontrib>Yurekli, B. S.</creatorcontrib><creatorcontrib>Kocabas, G. U.</creatorcontrib><creatorcontrib>Tuluce, K.</creatorcontrib><creatorcontrib>Tuluce, S. Y.</creatorcontrib><creatorcontrib>Kocabas, U.</creatorcontrib><creatorcontrib>Bozkaya, G.</creatorcontrib><creatorcontrib>Yuksel, A.</creatorcontrib><creatorcontrib>Nazli, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akyildiz, Z. I.</au><au>Polat, S.</au><au>Yurekli, B. S.</au><au>Kocabas, G. U.</au><au>Tuluce, K.</au><au>Tuluce, S. Y.</au><au>Kocabas, U.</au><au>Bozkaya, G.</au><au>Yuksel, A.</au><au>Nazli, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>38</volume><issue>3</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>1720-8386</issn><eissn>1720-8386</eissn><abstract>Purpose The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles. Methods Forty-five obese premenopausal women with body mass index (BMI) ≥30 kg/m 2 and 41 control premenopausal women with BMI &lt;25 kg/m 2 with similar SCORE project risk profiles were included in this case–control study. EFT was evaluated by two-dimensional transthoracic echocardiography. Serum FGF-21 was measured with an ELISA kit. Results FGF-21 and EFT were significantly higher in obese women compared to controls ( p  &lt; 0.001). Multiple stepwise linear regression analysis showed that EFT, BMI, and triglycerides (TG) independently contributed to FGF-21 ( R 2  = 0.757, p  &lt; 0.001). However, homeostasis model assessment of insulin resistance (HOMA-IR), visceral ectopic fat, and inflammatory markers were not found as a direct contributor to serum FGF-21 level ( p  &gt; 0.05). Conclusions EFT, BMI, and TG may play an important role in predicting serum FGF-21 level which may be a potential therapeutic target in cardiometabolic disorders in the future.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>25312836</pmid><doi>10.1007/s40618-014-0185-3</doi><tpages>6</tpages></addata></record>
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subjects Adult
Body Mass Index
Case-Control Studies
Endocrinology
Female
Fibroblast Growth Factors - blood
Humans
Insulin Resistance - physiology
Intra-Abdominal Fat - metabolism
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity - blood
Obesity - metabolism
Original Article
Pericardium
Premenopause
Triglycerides - blood
title Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women
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