Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease

Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by brain atrophy particularly in striatum leading to personality changes, chorea and dementia. Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase in the crossroad of many signaling pathways that is h...

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Veröffentlicht in:	Human molecular genetics 2015-09, Vol.24 (17), p.5040-5052
Hauptverfasser:	Fernández-Nogales, Marta, Hernández, Félix, Miguez, Andrés, Alberch, Jordi, Ginés, Silvia, Pérez-Navarro, Esther, Lucas, José J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Atrophy Brain - metabolism Brain - pathology Case-Control Studies Cognition Disease Models, Animal Enzyme Activation Female Gene Expression Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Humans Huntington Disease - diagnosis Huntington Disease - genetics Huntington Disease - metabolism Male Mice Mice, Transgenic Middle Aged Motor Activity - genetics Phenotype
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