Simvastatin downregulates expression of TGF-βRII and inhibits proliferation of A549 cells via ERK

Lung cancer is the leading cause of cancer-related death worldwide. Transforming growth factor-β receptor II (TGF-βRII) plays an important role in the regulation of proliferation and progression in cancer. Statins have been documented to exhibit anticancer and cancer chemopreventive properties. Howe...

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Veröffentlicht in:	Tumor biology 2015-06, Vol.36 (6), p.4819-4824
Hauptverfasser:	Shang, Li, Jia, Shu-Shan, Jiang, Hai-Ming, Wang, Hua, Xu, Wen-Hua, Lv, Chang-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cancer Research Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Extracellular Signal-Regulated MAP Kinases - biosynthesis Extracellular Signal-Regulated MAP Kinases - genetics Gene Expression Regulation, Neoplastic - drug effects Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Polyisoprenyl Phosphates - administration & dosage Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - genetics Receptors, Transforming Growth Factor beta - biosynthesis Receptors, Transforming Growth Factor beta - genetics Research Article Sesquiterpenes - administration & dosage Simvastatin - administration & dosage
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