Quinoxaline, its derivatives and applications: A State of the Art review
Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perfo...
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| Veröffentlicht in: | European journal of medicinal chemistry 2015-06, Vol.97, p.664-672 |
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| container_title | European journal of medicinal chemistry |
| container_volume | 97 |
| creator | Pereira, Joana A. Pessoa, Ana M. Cordeiro, M. Natália D.S. Fernandes, Rúben Prudêncio, Cristina Noronha, João Paulo Vieira, Mónica |
| description | Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform.
In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value.
Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
[Display omitted]
•Quinoxaline and its' derivatives are compounds with multiple potential applications.•We present biological applications of quinoxaline and derivatives already studied.•Quinoxaline based compounds are of great medicinal–biological interest. |
| doi_str_mv | 10.1016/j.ejmech.2014.06.058 |
| format | Article |
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In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value.
Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
[Display omitted]
•Quinoxaline and its' derivatives are compounds with multiple potential applications.•We present biological applications of quinoxaline and derivatives already studied.•Quinoxaline based compounds are of great medicinal–biological interest.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2014.06.058</identifier><identifier>PMID: 25011559</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Animals ; Biological activity ; Biomedical applications ; Chronic Disease - drug therapy ; Drug Discovery - methods ; Humans ; Metabolic Diseases - drug therapy ; Quinoxaline ; Quinoxaline derivatives ; Quinoxalines - chemistry ; Quinoxalines - pharmacology ; Quinoxalines - therapeutic use ; Therapeutic application</subject><ispartof>European journal of medicinal chemistry, 2015-06, Vol.97, p.664-672</ispartof><rights>2014 Elsevier Masson SAS</rights><rights>Copyright © 2014 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-5903f2d4ab6b28bb809822053586f8b2b72ee0f2d4333fed118ff278fb61c35d3</citedby><cites>FETCH-LOGICAL-c577t-5903f2d4ab6b28bb809822053586f8b2b72ee0f2d4333fed118ff278fb61c35d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S022352341400587X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25011559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pereira, Joana A.</creatorcontrib><creatorcontrib>Pessoa, Ana M.</creatorcontrib><creatorcontrib>Cordeiro, M. Natália D.S.</creatorcontrib><creatorcontrib>Fernandes, Rúben</creatorcontrib><creatorcontrib>Prudêncio, Cristina</creatorcontrib><creatorcontrib>Noronha, João Paulo</creatorcontrib><creatorcontrib>Vieira, Mónica</creatorcontrib><title>Quinoxaline, its derivatives and applications: A State of the Art review</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform.
In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value.
Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
[Display omitted]
•Quinoxaline and its' derivatives are compounds with multiple potential applications.•We present biological applications of quinoxaline and derivatives already studied.•Quinoxaline based compounds are of great medicinal–biological interest.</description><subject>Animals</subject><subject>Biological activity</subject><subject>Biomedical applications</subject><subject>Chronic Disease - drug therapy</subject><subject>Drug Discovery - methods</subject><subject>Humans</subject><subject>Metabolic Diseases - drug therapy</subject><subject>Quinoxaline</subject><subject>Quinoxaline derivatives</subject><subject>Quinoxalines - chemistry</subject><subject>Quinoxalines - pharmacology</subject><subject>Quinoxalines - therapeutic use</subject><subject>Therapeutic application</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVoqB23_yAUHXvIbkbSSivnEDAmX2AoJelZaLUjIrPedSXZSf991zjJMaeB4XnnZR5CzhmUDJi6XJe43qB7LjmwqgRVgtQnZMpqpQvBZfWFTIFzUUguqgk5S2kNAFIBfCUTLoExKedTcv97F_rh1XahxwsacqItxrC3OewxUdu31G63XXDjYujTFV3Qx2wz0sHT_Ix0ETONuA_48o2cetsl_P42Z-TP7c3T8r5Y_bp7WC5WhZN1nQs5B-F5W9lGNVw3jYa55hykkFp53fCm5ohwIIQQHlvGtPe81r5RzAnZihn5eby7jcPfHaZsNiE57Drb47BLhtXAlWScz0e0OqIuDilF9GYbw8bGf4aBOTg0a3N0aA4ODSgzOhxjP94ads0G24_Qu7QRuD4COP45_h5NcgF7h22I6LJph_B5w387NoM2</recordid><startdate>20150605</startdate><enddate>20150605</enddate><creator>Pereira, Joana A.</creator><creator>Pessoa, Ana M.</creator><creator>Cordeiro, M. Natália D.S.</creator><creator>Fernandes, Rúben</creator><creator>Prudêncio, Cristina</creator><creator>Noronha, João Paulo</creator><creator>Vieira, Mónica</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150605</creationdate><title>Quinoxaline, its derivatives and applications: A State of the Art review</title><author>Pereira, Joana A. ; Pessoa, Ana M. ; Cordeiro, M. Natália D.S. ; Fernandes, Rúben ; Prudêncio, Cristina ; Noronha, João Paulo ; Vieira, Mónica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-5903f2d4ab6b28bb809822053586f8b2b72ee0f2d4333fed118ff278fb61c35d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biological activity</topic><topic>Biomedical applications</topic><topic>Chronic Disease - drug therapy</topic><topic>Drug Discovery - methods</topic><topic>Humans</topic><topic>Metabolic Diseases - drug therapy</topic><topic>Quinoxaline</topic><topic>Quinoxaline derivatives</topic><topic>Quinoxalines - chemistry</topic><topic>Quinoxalines - pharmacology</topic><topic>Quinoxalines - therapeutic use</topic><topic>Therapeutic application</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pereira, Joana A.</creatorcontrib><creatorcontrib>Pessoa, Ana M.</creatorcontrib><creatorcontrib>Cordeiro, M. Natália D.S.</creatorcontrib><creatorcontrib>Fernandes, Rúben</creatorcontrib><creatorcontrib>Prudêncio, Cristina</creatorcontrib><creatorcontrib>Noronha, João Paulo</creatorcontrib><creatorcontrib>Vieira, Mónica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pereira, Joana A.</au><au>Pessoa, Ana M.</au><au>Cordeiro, M. Natália D.S.</au><au>Fernandes, Rúben</au><au>Prudêncio, Cristina</au><au>Noronha, João Paulo</au><au>Vieira, Mónica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quinoxaline, its derivatives and applications: A State of the Art review</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2015-06-05</date><risdate>2015</risdate><volume>97</volume><spage>664</spage><epage>672</epage><pages>664-672</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><abstract>Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform.
In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value.
Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
[Display omitted]
•Quinoxaline and its' derivatives are compounds with multiple potential applications.•We present biological applications of quinoxaline and derivatives already studied.•Quinoxaline based compounds are of great medicinal–biological interest.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>25011559</pmid><doi>10.1016/j.ejmech.2014.06.058</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of medicinal chemistry, 2015-06, Vol.97, p.664-672 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological activity Biomedical applications Chronic Disease - drug therapy Drug Discovery - methods Humans Metabolic Diseases - drug therapy Quinoxaline Quinoxaline derivatives Quinoxalines - chemistry Quinoxalines - pharmacology Quinoxalines - therapeutic use Therapeutic application |
| title | Quinoxaline, its derivatives and applications: A State of the Art review |
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