ERK/GSK3β signaling is involved in atractylenolide I-induced apoptosis and cell cycle arrest in melanoma cells

Novel agents need to be developed to overcome the limitations of the current melanoma therapeutics. Atractylenolide I (AT-I) is a sesquiterpene compound isolated from atractylodis macrocephalae rhizoma. Previous findings demonstrated that AT-I exhibited cytotoxic action in melanoma cells. However, t...

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Veröffentlicht in:	Oncology reports 2015-09, Vol.34 (3), p.1543-1548
Hauptverfasser:	YE, YAN, CHAO, XIAO-JUAN, WU, JIN-FENG, CHENG, BRIAN CHI-YAN, SU, TAO, FU, XIU-QIONG, LI, TING, GUO, HUI, TSE, ANFERNEE KAI-WING, KWAN, HIU-YEE, DU, JUAN, CHOU, GUI-XIN, YU, ZHI-LING
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects atractylenolide I Cell cycle Cell Cycle Checkpoints - drug effects Cell growth Cell Proliferation - drug effects Cellular signal transduction Cytotoxicity Development and progression ERK Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Glycogen Synthase Kinase 3 - biosynthesis Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 beta GSK3β Health aspects Humans Immunoglobulins Kinases Lactones - administration & dosage Melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - genetics Melanoma, Experimental - pathology Mice Mitogen-Activated Protein Kinase 3 - biosynthesis Mitogen-Activated Protein Kinase 3 - genetics Neoplasm Proteins - biosynthesis Phosphorylation Proteins Sesquiterpenes Sesquiterpenes - administration & dosage Signal Transduction - drug effects Skin cancer Tumor necrosis factor-TNF
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