Cloning, expression and characterization of the P64k outer membrane protein from N. meningitidis
Meningococcal meningitis as an endemic disease occurs with a frequency of approximately 0.5-5 per 100 000 per year in a great part of the world. Epidemic disease has been reported from all continents in the last few years. The serogroups A, B and C are the main cause of the disease. The group B N. m...
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| Veröffentlicht in: | Biotecnología aplicada 1995-01, Vol.12 (2), p.72-72 |
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| container_issue | 2 |
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| container_title | Biotecnología aplicada |
| container_volume | 12 |
| creator | Guillen, G Silva, R Alvarez, A Novoa, LI Gonzalez, S Musacchio, A Selman, M Martin, A Morera, V Fernandez, J Morales, J Sierra, G Besada, V Coizeau, E |
| description | Meningococcal meningitis as an endemic disease occurs with a frequency of approximately 0.5-5 per 100 000 per year in a great part of the world. Epidemic disease has been reported from all continents in the last few years. The serogroups A, B and C are the main cause of the disease. The group B N. meningitidis polysaccharide (PS) in contrast to group A, C, and others is a poor immunogen in humans due to immunological tolerance and structural similarities that have been found in developing fetal brain tissue. Therefore, the strategy of vaccine against serogroup B should be based in strains of N. meningitidis, could be an effective approach to confer protection against meningococcal disease in humans. |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0864-4551 |
| ispartof | Biotecnología aplicada, 1995-01, Vol.12 (2), p.72-72 |
| issn | 0864-4551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17025556 |
| source | DOAJ Directory of Open Access Journals; Bioline International; Alma/SFX Local Collection |
| subjects | Neisseria meningitidis |
| title | Cloning, expression and characterization of the P64k outer membrane protein from N. meningitidis |
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