Effects of the nitro-group on the mutagenicity and toxicity of some benzamines

The Ames Salmonella/microsomal assay was employed to test the mutagenicity of some benzamines (aniline, and o‐ and p‐phenylenediamine) and their nitro‐derivatives (p‐nitroaniline, 2‐nitro‐p‐phenylenediamine 3‐ and 4‐nitro‐o‐phenylenediamine), using strains TA98) and TA100 and their nitroreductase‐de...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1996, Vol.27 (1), p.67-74
Hauptverfasser:	Chung, King-Thom, Murdock, Chris A., Zhou, Yonggui, Stevens Jr, S. Edward, Li, Ying-Sing, Wei, Cheng-I., Fernando, S. Y., Chou, Ming-W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - chemistry Aniline Compounds - toxicity Animals benzamines Biological and medical sciences Biotransformation Cell Survival - drug effects Chemical mutagenesis Chemical Phenomena Chemistry, Physical CHO Cells - drug effects chromosomal aberrations Chromosome Aberrations Cricetinae cytotoxicity Dose-Response Relationship, Drug Male Medical sciences Molecular Structure mutagenicity Mutagenicity Tests Nitro Compounds - chemistry Nitro Compounds - toxicity Nitroreductases - deficiency Nitroreductases - metabolism Oxidation-Reduction oxidative potential Phenylenediamines - chemistry Phenylenediamines - toxicity Rats Rats, Sprague-Dawley Salmonella typhimurium - drug effects Structure-Activity Relationship Toxicology
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