Excitatory amino acid‐, except 1S,3R‐ACPD, induced transient high stimulation of phosphoinositide metabolism during hippocampal neuron development

Rat hippocampal neurons in culture extended their neurites until day 5 in vitro (DIV). Then, the mean neuritic length slightly decreased. Excitatory amino acid (EAA)‐elicited inositol phosphate (IP) formation increased from 0.5 to 2 DIV, reached a plateau between 2 and 4–5 DIV, and then gradually de...

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Veröffentlicht in:	International journal of developmental neuroscience 1995-11, Vol.13 (7), p.723-737
Hauptverfasser:	Blanc, Emmanuelle M., Vignes, Michel H., Récasens, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	3R‐ACPD Animals Cells, Cultured Cycloleucine - analogs & derivatives Cycloleucine - pharmacology development Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology excitatory amino acids Excitatory Amino Acids - pharmacology hippocampal neurons in culture Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Membrane Lipids - metabolism metabotropic glutamate receptor subtypes Neurites - metabolism Neurites - ultrastructure Neurons - metabolism Neurons - ultrastructure Neurotoxins - pharmacology Phosphatidylinositols - metabolism phosphoinositide metabolism Rats Receptors, Metabotropic Glutamate - drug effects Stimulation, Chemical
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