Adverse Events Associated with High-Dose Rifabutin in Macrolide-Containing Regimens for the Treatment of Mycobacterium avium Complex Lung Disease

We initiated a multidrug trial that included high-dose rifabutin for the treatment of pulmonary Mycobacterium avium complex (MAC) disease. Twenty-six patients received rifabutin (600 mg/d) in combination with ethambutol, streptomycin, and either clarithromycin (500 mg b.i.d.; 15 patients) or azithro...

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Veröffentlicht in:	Clinical infectious diseases 1995-09, Vol.21 (3), p.594-598
Hauptverfasser:	Griffith, David E., Brown, Barbara A., Girard, William M., Wallace, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AIDS Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Arthralgia Arthralgia - chemically induced Biological and medical sciences Clinical Articles Digestive System - drug effects Dosage Drug Interactions Drug Therapy, Combination - administration & dosage Drug Therapy, Combination - adverse effects Drug Tolerance Enzymes Female Humans Leukopenia - chemically induced Liver Liver - drug effects Liver - enzymology Lung diseases Lung Diseases - drug therapy Macrolides Male Medical sciences Middle Aged Mycobacterium avium complex Mycobacterium avium-intracellulare Infection - drug therapy Pharmacology. Drug treatments Platelets Rifabutin - administration & dosage Rifabutin - adverse effects Uveitis
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