Cytoplasmic sequestration of wild-type p53 protein impairs the G sub(1) checkpoint after DNA damage

Wild-type p53 protein is abnormally sequestered in the cytoplasm of a subset of primary human tumors including neuroblastomas (NB). This may represent a nonmutational mechanism for abrogating p53 tumor suppressor function. To test this hypothesis, we established the first available in vitro model th...

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Veröffentlicht in:	Molecular and cellular biology 1996-01, Vol.16 (3), p.1126-1137
Hauptverfasser:	Moll, U M, Ostermeyer, A G, Haladay, R, Winkfield, B, Frazier, M, Zambetti, G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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