The Safety Evaluation of Fluvastatin, an HMG–CoA Reductase Inhibitor, in Beagle Dogs and Rhesus Monkeys

Fluvastatin is a potent synthetic competitive inhibitor of β-hydroxy-β-methyl-glutaryl-coenzyme A (HMG–CoA) reductase, the rate-limiting enzyme in the biosynthetic pathway for hepatic cholesterol synthesis. The therapeutic indication is reduction of elevated total and low-density lipoprotein cholest...

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Veröffentlicht in:	Fundamental and applied toxicology 1996-01, Vol.29 (1), p.48-62
Hauptverfasser:	Hartman, Howard A., Myers, Laurie A., Evans, Morton, Robison, Rodney L., Engstrom, Robert G., Tse, Francis L.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Body Weight - drug effects Cataract - chemically induced Dogs Drug toxicity and drugs side effects treatment Eating - drug effects Fatty Acids, Monounsaturated - administration & dosage Fatty Acids, Monounsaturated - chemistry Fatty Acids, Monounsaturated - pharmacokinetics Fatty Acids, Monounsaturated - toxicity Female Fluvastatin Hydroxymethylglutaryl-CoA Reductase Inhibitors Indoles - administration & dosage Indoles - chemistry Indoles - pharmacokinetics Indoles - toxicity Lens, Crystalline - chemistry Lens, Crystalline - drug effects Lipids - blood Liver - drug effects Liver - enzymology Macaca mulatta Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Time Factors
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