Protein microarrays as an application for disease biomarkers
Protein microarrays are an increasingly powerful technology in the hunt for new and novel diagnostic and prognostic biomarkers. Lending credit to the highly established DNA microarray, protein microarrays are versatile tools that utilize a variety of formats to facilitate the discovery of new biomar...
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| Veröffentlicht in: | Proteomics. Clinical applications 2009-02, Vol.3 (2), p.138-147 |
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| container_title | Proteomics. Clinical applications |
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| creator | Caiazzo Jr, Robert J. Maher, Andrew J. Drummond, Michael P. Lander, Corey I. Tassinari, Oliver W. Nelson, Bryce P. Liu, Brian C.-S. |
| description | Protein microarrays are an increasingly powerful technology in the hunt for new and novel diagnostic and prognostic biomarkers. Lending credit to the highly established DNA microarray, protein microarrays are versatile tools that utilize a variety of formats to facilitate the discovery of new biomarkers and our understanding of disease pathways. The aims of this review are: to detail a variety of protein microarray technologies currently used, including forward‐phase technologies and reverse‐phase technologies useful in both the discovery and validation of candidate biomarkers; to explore the strengths and weaknesses of various proteomic microarray platforms; to explain how bioinformatics helps compare data between microarray data sets; and to discuss the downstream applications of such technologies as they relate to the development of a highly personalized approach to medicine. |
| doi_str_mv | 10.1002/prca.200800149 |
| format | Article |
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| ispartof | Proteomics. Clinical applications, 2009-02, Vol.3 (2), p.138-147 |
| issn | 1862-8346 1862-8354 |
| language | eng |
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| source | Access via Wiley Online Library |
| subjects | Autoantibody microarrays Bioinformatics Biological and medical sciences Diverse techniques Forward-phase microarrays Fundamental and applied biological sciences. Psychology General aspects Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Molecular and cellular biology Multiplex Reverse-phase microarrays |
| title | Protein microarrays as an application for disease biomarkers |
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