Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia–reperfusion

Abstract Background/objectives : Opening of the mitochondrial permeability transition pore (mPTP) is involved in ischemia–reperfusion injury. Isoforms of Ca 2 + -activated cysteine proteases, calpains, are implicated in the development of myocardial infarction in ischemia–reperfusion. Growing eviden...

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Veröffentlicht in:	International journal of cardiology 2015-10, Vol.197, p.26-32
Hauptverfasser:	Shintani-Ishida, Kaori, Yoshida, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Calcium Calcium - pharmacology Calpain Calpain - antagonists & inhibitors Calpain - pharmacology Cardiovascular Dipeptides - pharmacology Female Humans Ischemia–reperfusion injury Male Middle Aged Mitochondria Mitochondria, Heart - enzymology Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial permeability transition pore Myocardial Reperfusion Injury - enzymology Rats Rats, Sprague-Dawley Young Adult
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