Inhibition by spinal morphine of the tail-flick response is attenuated in rats with nerve ligation injury

Nerve ligation injury in rats produces increased sensitivity and exaggerated responses to nociceptive stimuli (hyperalgesia) as well as nociceptive responses to normally innocuous stimuli (allodynia) analogous to clinical conditions of neuropathic pain. However, the effect of nerve injury on acute n...

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Veröffentlicht in:	Neuroscience letters 1995-10, Vol.199 (2), p.83-86
Hauptverfasser:	Ossipov, Michael H., Lopez, Yvan, Nichols, Michael L., Bian, Di, Porreca, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Dose-Response Relationship, Drug Injections, Spinal Ligation Male Medical sciences Morphine Morphine - administration & dosage Morphine - pharmacology Nerve ligation injury Nervous system (semeiology, syndromes) Neurology Pain Measurement - drug effects Rats Rats, Sprague-Dawley Sciatic Nerve - injuries Tail-flick latency
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