Occupational exposure to bidi tobacco increases chromosomal aberrations in tobacco processors
In India, workers engaged in processing of tobacco for the manufacture of bidis (the indogenous substitute for cigarettes) are chronically exposed to tobacco flakes and dust via the cutaneous and nasopharyngeal routes. Hence, workers in a tobacco processing factory were monitored for chromosomal abe...
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| Veröffentlicht in: | Mutation Research 1995-04, Vol.334 (2), p.139-144 |
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| container_title | Mutation Research |
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| creator | Mahimkar, Manoj B. Bhisey, Rajani A. |
| description | In India, workers engaged in processing of tobacco for the manufacture of bidis (the indogenous substitute for cigarettes) are chronically exposed to tobacco flakes and dust via the cutaneous and nasopharyngeal routes. Hence, workers in a tobacco processing factory were monitored for chromosomal aberrations (CA) using peripheral blood lymphocytes as the test system. Cytogenetic analysis revealed a significant increase in deletion fragments and chromatid gaps in the exposed group. The frequency of aberrant metaphases and the proportion of individuals with CA were significantly higher in workers than in controls, indicating that occupational exposure to tobacco imposes considerable genotoxicity among tobacco processors. |
| doi_str_mv | 10.1016/0165-1161(95)90004-7 |
| format | Article |
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Hence, workers in a tobacco processing factory were monitored for chromosomal aberrations (CA) using peripheral blood lymphocytes as the test system. Cytogenetic analysis revealed a significant increase in deletion fragments and chromatid gaps in the exposed group. 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| fulltext | fulltext |
| identifier | ISSN: 0165-1161 |
| ispartof | Mutation Research, 1995-04, Vol.334 (2), p.139-144 |
| issn | 0165-1161 0027-5107 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biological and medical sciences Chemical mutagenesis Chi-Square Distribution Chromosomal aberrations Chromosome Aberrations Female Humans India Lymphocytes - drug effects Medical sciences Middle Aged Occupational exposure Occupational Exposure - adverse effects Plants, Toxic Smokeless tobacco Tobacco, Smokeless - adverse effects Toxicology |
| title | Occupational exposure to bidi tobacco increases chromosomal aberrations in tobacco processors |
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