Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo

The present study assessed the ability of optogenetics techniques to provide a better understanding of the control of insulin secretion, particularly regarding pancreatic β-cell function in homeostasis and pathological conditions such as diabetes mellitus (DM). We used optogenetics to investigate wh...

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Veröffentlicht in:	Gene therapy 2015-07, Vol.22 (7), p.553-559
Hauptverfasser:	Kushibiki, T, Okawa, S, Hirasawa, T, Ishihara, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1513 96 Adenylate cyclase Adenylyl Cyclases - metabolism Animals Beta cells Biomedical and Life Sciences Biomedicine Blood glucose Blood Glucose - metabolism Ca2+/calmodulin-dependent protein kinase II Calcium (intracellular) Calcium - metabolism Calcium-binding protein Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calmodulin Care and treatment Cell Biology Cells, Cultured Channelrhodopsins Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - radiotherapy Gene Expression Gene Therapy Genetics Glucose Glucose tolerance Growth factors Health aspects Homeostasis Human Genetics Information processing Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - radiation effects Kinases Low-Level Light Therapy - methods Metabolic disorders Mice Nanotechnology Neurophysiology Optics Optogenetics original-article Pancreas Secretion Streptozocin
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