Detection of aneuploidy from single fetal nucleated red blood cells using whole genome sequencing

Objective The objective of the study was to detect aneuploidy in single fetal nucleated red blood cells (FNRBCs) from placental villi using whole genome amplification (WGA) and next generation sequencing. Methods Three single FNRBCs per sample were manually picked from villi collected from ten women...

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Veröffentlicht in:	Prenatal diagnosis 2015-07, Vol.35 (7), p.637-644
Hauptverfasser:	Hua, Rui, Barrett, Angela N., Tan, Tuan Zea, Huang, Zhouwei, Mahyuddin, Aniza Puteri, Ponnusamy, Sukumar, Sandhu, Jaspal Singh, Ho, Sherry S. Y., Chan, Jerry K. Y., Chong, Samuel, Quan, Song, Choolani, Mahesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Chorionic Villi Sampling Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 18 - genetics Down Syndrome - diagnosis Down Syndrome - genetics Erythroblasts Female Genome, Human High-Throughput Nucleotide Sequencing Humans Karyotyping - methods Male Pregnancy Pregnancy Trimester, First Sequence Analysis, DNA - methods Trisomy - diagnosis Trisomy - genetics Trisomy 18 Syndrome
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