Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19

A dynamic G-quadruplex region has been previously shown to form in the long terminal repeat (LTR) promoter of the HIV-1 integrated DNA genome. Inhibition of promoter activity and antiviral effects have been observed when this region was stabilized by BRACO-19, a trisubstituted acridine derivative th...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2014-12, Vol.69 (12), p.3248-3258
Hauptverfasser:	Perrone, Rosalba, Butovskaya, Elena, Daelemans, Dirk, Palù, Giorgio, Pannecouque, Christophe, Richter, Sara N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacology Anti-HIV Agents - pharmacology Biophysics Cells Deoxyribonucleic acid DNA G-Quadruplexes - drug effects HIV HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Inhibitory Concentration 50 Microbial Sensitivity Tests Microbial Viability - drug effects Proviruses - drug effects Reverse Transcription - drug effects Ribonucleic acid RNA RNA, Viral - drug effects
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