VEGF and its receptors in dengue virus infection
Vascular permeability determines the severity of dengue virus infection. Vascular endothelial growth factor (VEGF) and its (receptor 1) R1 and (receptor 2) R2 receptors may provide insight about the neurological complications of dengue. We report VEGF and its R1 and R2 receptors level in dengue pati...
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| Veröffentlicht in: | Journal of medical virology 2015-09, Vol.87 (9), p.1449-1455 |
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| creator | Kalita, J. Chauhan, P. S. Mani, V. E. Bhoi, S. K. Misra, U. K. |
| description | Vascular permeability determines the severity of dengue virus infection. Vascular endothelial growth factor (VEGF) and its (receptor 1) R1 and (receptor 2) R2 receptors may provide insight about the neurological complications of dengue. We report VEGF and its R1 and R2 receptors level in dengue patients and correlate these with neurological complications. Consecutive patients with dengue were subjected to clinical and neurological evaluations. Their blood counts, serum chemistry, including liver and kidney function tests, serum creatine kinase (CK), and albumin were measured. VEGF, VEGFR1 and VEGFR2 were measured by ELISA in the patients and 16 matched controls. Twenty four patients with dengue were included whose ages ranged between 15 and 67 years, and nine of whom were females. Serum VEGF level was insignificantly lower in dengue patients whereas VEGFR1 was significantly higher (P = 0.01) and VEGFR2 was significantly lower (P = 0.005) compared to controls. VEGFR2 correlated with systolic blood pressure, coagulopathy, and serum CK levels. None of the other clinical and biochemical parameters correlated with VEGF and VEGFR1 levels. VEGFR1 and R2 normalized at 1 month. VEGFR2 correlates with the clinical severity of dengue and muscle dysfunction. J. Med. Virol. 87:1449–1455, 2015. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.24205 |
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S. ; Mani, V. E. ; Bhoi, S. K. ; Misra, U. K.</creator><creatorcontrib>Kalita, J. ; Chauhan, P. S. ; Mani, V. E. ; Bhoi, S. K. ; Misra, U. K.</creatorcontrib><description>Vascular permeability determines the severity of dengue virus infection. Vascular endothelial growth factor (VEGF) and its (receptor 1) R1 and (receptor 2) R2 receptors may provide insight about the neurological complications of dengue. We report VEGF and its R1 and R2 receptors level in dengue patients and correlate these with neurological complications. Consecutive patients with dengue were subjected to clinical and neurological evaluations. Their blood counts, serum chemistry, including liver and kidney function tests, serum creatine kinase (CK), and albumin were measured. VEGF, VEGFR1 and VEGFR2 were measured by ELISA in the patients and 16 matched controls. Twenty four patients with dengue were included whose ages ranged between 15 and 67 years, and nine of whom were females. Serum VEGF level was insignificantly lower in dengue patients whereas VEGFR1 was significantly higher (P = 0.01) and VEGFR2 was significantly lower (P = 0.005) compared to controls. VEGFR2 correlated with systolic blood pressure, coagulopathy, and serum CK levels. None of the other clinical and biochemical parameters correlated with VEGF and VEGFR1 levels. VEGFR1 and R2 normalized at 1 month. VEGFR2 correlates with the clinical severity of dengue and muscle dysfunction. J. Med. 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S.</creatorcontrib><creatorcontrib>Mani, V. E.</creatorcontrib><creatorcontrib>Bhoi, S. K.</creatorcontrib><creatorcontrib>Misra, U. K.</creatorcontrib><title>VEGF and its receptors in dengue virus infection</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Vascular permeability determines the severity of dengue virus infection. Vascular endothelial growth factor (VEGF) and its (receptor 1) R1 and (receptor 2) R2 receptors may provide insight about the neurological complications of dengue. We report VEGF and its R1 and R2 receptors level in dengue patients and correlate these with neurological complications. Consecutive patients with dengue were subjected to clinical and neurological evaluations. Their blood counts, serum chemistry, including liver and kidney function tests, serum creatine kinase (CK), and albumin were measured. VEGF, VEGFR1 and VEGFR2 were measured by ELISA in the patients and 16 matched controls. Twenty four patients with dengue were included whose ages ranged between 15 and 67 years, and nine of whom were females. Serum VEGF level was insignificantly lower in dengue patients whereas VEGFR1 was significantly higher (P = 0.01) and VEGFR2 was significantly lower (P = 0.005) compared to controls. VEGFR2 correlated with systolic blood pressure, coagulopathy, and serum CK levels. None of the other clinical and biochemical parameters correlated with VEGF and VEGFR1 levels. VEGFR1 and R2 normalized at 1 month. VEGFR2 correlates with the clinical severity of dengue and muscle dysfunction. J. Med. Virol. 87:1449–1455, 2015. © 2015 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>creatine kinase</subject><subject>dengue</subject><subject>Dengue - blood</subject><subject>Dengue - complications</subject><subject>Dengue - physiopathology</subject><subject>Dengue fever</subject><subject>Dengue virus</subject><subject>encephalitis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscular Diseases - etiology</subject><subject>Muscular Diseases - virology</subject><subject>myopathy</subject><subject>outcome</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - blood</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - chemistry</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - blood</subject><subject>VEGF</subject><subject>VEGF receptors</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0EtLw0AUBeBBFK3VhX9AAm50Eb0zmedSgq2Wqhut4mZIkxtJTZM6k_j496ZWXQiCq2HguwfOIWSPwjEFYCez-csx4wzEGulRMDI0oOg66QHlMpSSii2y7f0MALRhbJNsMWEUUEl7BCZnw0GQVFlQND5wmOKiqZ0PiirIsHpsMXgpXLv855g2RV3tkI08KT3ufr19cjs4u4nPw_H18CI-HYcpN1yEWjJUKtegOU6ppkZnOk0zYHIaGZ4kPDFSKA3cIAolxJQz5MCVkpzRrkvUJ4er3IWrn1v0jZ0XPsWyTCqsW29pV4BrraJ_UGkUY2CM7ujBLzqrW1d1RZZKAucSRKeOVip1tfcOc7twxTxx75aCXS5uu8Xt5-Kd3f9KbKdzzH7k98QdOFmB16LE97-T7Ohy8h0Zri4K3-Dbz0XinqxUkRL27mpoH0YxxIP72JroA74UlLE</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Kalita, J.</creator><creator>Chauhan, P. 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K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4945-862e77f8084eb18198d8ccd026b394aa4a96578049ee5755b42e4047764212423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>creatine kinase</topic><topic>dengue</topic><topic>Dengue - blood</topic><topic>Dengue - complications</topic><topic>Dengue - physiopathology</topic><topic>Dengue fever</topic><topic>Dengue virus</topic><topic>encephalitis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscular Diseases - etiology</topic><topic>Muscular Diseases - virology</topic><topic>myopathy</topic><topic>outcome</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - blood</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - chemistry</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - blood</topic><topic>VEGF</topic><topic>VEGF receptors</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalita, J.</creatorcontrib><creatorcontrib>Chauhan, P. 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S.</au><au>Mani, V. E.</au><au>Bhoi, S. K.</au><au>Misra, U. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VEGF and its receptors in dengue virus infection</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2015-09</date><risdate>2015</risdate><volume>87</volume><issue>9</issue><spage>1449</spage><epage>1455</epage><pages>1449-1455</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Vascular permeability determines the severity of dengue virus infection. Vascular endothelial growth factor (VEGF) and its (receptor 1) R1 and (receptor 2) R2 receptors may provide insight about the neurological complications of dengue. We report VEGF and its R1 and R2 receptors level in dengue patients and correlate these with neurological complications. Consecutive patients with dengue were subjected to clinical and neurological evaluations. Their blood counts, serum chemistry, including liver and kidney function tests, serum creatine kinase (CK), and albumin were measured. VEGF, VEGFR1 and VEGFR2 were measured by ELISA in the patients and 16 matched controls. Twenty four patients with dengue were included whose ages ranged between 15 and 67 years, and nine of whom were females. Serum VEGF level was insignificantly lower in dengue patients whereas VEGFR1 was significantly higher (P = 0.01) and VEGFR2 was significantly lower (P = 0.005) compared to controls. VEGFR2 correlated with systolic blood pressure, coagulopathy, and serum CK levels. None of the other clinical and biochemical parameters correlated with VEGF and VEGFR1 levels. VEGFR1 and R2 normalized at 1 month. VEGFR2 correlates with the clinical severity of dengue and muscle dysfunction. J. Med. 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| subjects | Adolescent Adult Aged creatine kinase dengue Dengue - blood Dengue - complications Dengue - physiopathology Dengue fever Dengue virus encephalitis Epidemiology Female Humans Male Middle Aged Muscular Diseases - etiology Muscular Diseases - virology myopathy outcome Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor Receptor-1 - blood Vascular Endothelial Growth Factor Receptor-1 - chemistry Vascular Endothelial Growth Factor Receptor-2 - blood VEGF VEGF receptors Virology Young Adult |
| title | VEGF and its receptors in dengue virus infection |
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