Infant birthweight and risk of childhood cancer: international population-based case control studies of 40 000 cases
High birthweight is an established risk factor for childhood leukaemia. Its association with other childhood cancers is less clear, with studies hampered by low case numbers. We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer....
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| Veröffentlicht in: | International journal of epidemiology 2015-02, Vol.44 (1), p.153-168 |
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| creator | O'Neill, Kate A Murphy, Michael Fg Bunch, Kathryn J Puumala, Susan E Carozza, Susan E Chow, Eric J Mueller, Beth A McLaughlin, Colleen C Reynolds, Peggy Vincent, Tim J Von Behren, Julie Spector, Logan G |
| description | High birthweight is an established risk factor for childhood leukaemia. Its association with other childhood cancers is less clear, with studies hampered by low case numbers.
We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer. Data for 16 554 cases and 53 716 controls were obtained by linkage of birth to cancer registration records across five US states, and 23 772 cases and 33 206 controls were obtained from the UK National Registry of Childhood Tumours. US, but not UK, data were adjusted for gestational age, birth order, plurality, and maternal age and race/ethnicity.
Risk associations were found between birthweight and several childhood cancers, with strikingly similar results between datasets. Total cancer risk increased linearly with each 0.5 kg increase in birthweight in both the US [odds ratio 1.06 (95% confidence interval 1.04, 1.08)] and UK [1.06 (1.05, 1.08)] datasets. Risk was strongest for leukaemia [USA: 1.10 (1.06, 1.13), UK: 1.07 (1.04, 1.10)], tumours of the central nervous system [USA: 1.05 (1.01, 1.08), UK: 1.07 (1.04, 1.10)], renal tumours [USA: 1.17 (1.10, 1.24), UK: 1.12 (1.06, 1.19)] and soft tissue sarcomas [USA: 1.12 (1.05, 1.20), UK: 1.07 (1.00, 1.13)]. In contrast, increasing birthweight decreased the risk of hepatic tumours [USA: 0.77 (0.69, 0.85), UK: 0.79 (0.71, 0.89) per 0.5 kg increase]. Associations were also observed between high birthweight and risk of neuroblastoma, lymphomas, germ cell tumours and malignant melanomas. For some cancer subtypes, risk associations with birthweight were non-linear. We observed no association between birthweight and risk of retinoblastoma or bone tumours.
Approximately half of all childhood cancers exhibit associations with birthweight. The apparent independence from other factors indicates the importance of intrauterine growth regulation in the aetiology of these diseases. |
| doi_str_mv | 10.1093/ije/dyu265 |
| format | Article |
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We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer. Data for 16 554 cases and 53 716 controls were obtained by linkage of birth to cancer registration records across five US states, and 23 772 cases and 33 206 controls were obtained from the UK National Registry of Childhood Tumours. US, but not UK, data were adjusted for gestational age, birth order, plurality, and maternal age and race/ethnicity.
Risk associations were found between birthweight and several childhood cancers, with strikingly similar results between datasets. Total cancer risk increased linearly with each 0.5 kg increase in birthweight in both the US [odds ratio 1.06 (95% confidence interval 1.04, 1.08)] and UK [1.06 (1.05, 1.08)] datasets. Risk was strongest for leukaemia [USA: 1.10 (1.06, 1.13), UK: 1.07 (1.04, 1.10)], tumours of the central nervous system [USA: 1.05 (1.01, 1.08), UK: 1.07 (1.04, 1.10)], renal tumours [USA: 1.17 (1.10, 1.24), UK: 1.12 (1.06, 1.19)] and soft tissue sarcomas [USA: 1.12 (1.05, 1.20), UK: 1.07 (1.00, 1.13)]. In contrast, increasing birthweight decreased the risk of hepatic tumours [USA: 0.77 (0.69, 0.85), UK: 0.79 (0.71, 0.89) per 0.5 kg increase]. Associations were also observed between high birthweight and risk of neuroblastoma, lymphomas, germ cell tumours and malignant melanomas. For some cancer subtypes, risk associations with birthweight were non-linear. We observed no association between birthweight and risk of retinoblastoma or bone tumours.
Approximately half of all childhood cancers exhibit associations with birthweight. The apparent independence from other factors indicates the importance of intrauterine growth regulation in the aetiology of these diseases.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyu265</identifier><identifier>PMID: 25626438</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Birth Order ; Birth Weight ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Male ; Multiple Birth Offspring ; Neoplasms - epidemiology ; Odds Ratio ; Risk Factors ; Sex Distribution ; Socioeconomic Factors ; United Kingdom - epidemiology ; United States - epidemiology</subject><ispartof>International journal of epidemiology, 2015-02, Vol.44 (1), p.153-168</ispartof><rights>The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-141f7f0c21442e90c81dce4b7afe3e422b048c3d29ed326cca6be1de1e5eb5d93</citedby><cites>FETCH-LOGICAL-c422t-141f7f0c21442e90c81dce4b7afe3e422b048c3d29ed326cca6be1de1e5eb5d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25626438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Neill, Kate A</creatorcontrib><creatorcontrib>Murphy, Michael Fg</creatorcontrib><creatorcontrib>Bunch, Kathryn J</creatorcontrib><creatorcontrib>Puumala, Susan E</creatorcontrib><creatorcontrib>Carozza, Susan E</creatorcontrib><creatorcontrib>Chow, Eric J</creatorcontrib><creatorcontrib>Mueller, Beth A</creatorcontrib><creatorcontrib>McLaughlin, Colleen C</creatorcontrib><creatorcontrib>Reynolds, Peggy</creatorcontrib><creatorcontrib>Vincent, Tim J</creatorcontrib><creatorcontrib>Von Behren, Julie</creatorcontrib><creatorcontrib>Spector, Logan G</creatorcontrib><title>Infant birthweight and risk of childhood cancer: international population-based case control studies of 40 000 cases</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>High birthweight is an established risk factor for childhood leukaemia. Its association with other childhood cancers is less clear, with studies hampered by low case numbers.
We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer. Data for 16 554 cases and 53 716 controls were obtained by linkage of birth to cancer registration records across five US states, and 23 772 cases and 33 206 controls were obtained from the UK National Registry of Childhood Tumours. US, but not UK, data were adjusted for gestational age, birth order, plurality, and maternal age and race/ethnicity.
Risk associations were found between birthweight and several childhood cancers, with strikingly similar results between datasets. Total cancer risk increased linearly with each 0.5 kg increase in birthweight in both the US [odds ratio 1.06 (95% confidence interval 1.04, 1.08)] and UK [1.06 (1.05, 1.08)] datasets. Risk was strongest for leukaemia [USA: 1.10 (1.06, 1.13), UK: 1.07 (1.04, 1.10)], tumours of the central nervous system [USA: 1.05 (1.01, 1.08), UK: 1.07 (1.04, 1.10)], renal tumours [USA: 1.17 (1.10, 1.24), UK: 1.12 (1.06, 1.19)] and soft tissue sarcomas [USA: 1.12 (1.05, 1.20), UK: 1.07 (1.00, 1.13)]. In contrast, increasing birthweight decreased the risk of hepatic tumours [USA: 0.77 (0.69, 0.85), UK: 0.79 (0.71, 0.89) per 0.5 kg increase]. Associations were also observed between high birthweight and risk of neuroblastoma, lymphomas, germ cell tumours and malignant melanomas. For some cancer subtypes, risk associations with birthweight were non-linear. We observed no association between birthweight and risk of retinoblastoma or bone tumours.
Approximately half of all childhood cancers exhibit associations with birthweight. The apparent independence from other factors indicates the importance of intrauterine growth regulation in the aetiology of these diseases.</description><subject>Adolescent</subject><subject>Birth Order</subject><subject>Birth Weight</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Multiple Birth Offspring</subject><subject>Neoplasms - epidemiology</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Socioeconomic Factors</subject><subject>United Kingdom - epidemiology</subject><subject>United States - epidemiology</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKBDEQRYMoOj42foBkKUJr5dUPdzL4AsGNrpt0Uu1Ee5IxSSP-vT2OunVVXOpwKeoQcszgnEEjLtwrXtjPkZdqi8yYLGUhylptkxkIgEJVFdsj-ym9AjApZbNL9rgqeSlFPSP53vfaZ9q5mBcf6F4WmWpvaXTpjYaemoUb7CIES432BuMldT5j9Dq74PVAV2E1Dt-h6HTCNZaQmuBzDANNebQO07pIAgWA73U6JDu9HhIe_cwD8nxz_TS_Kx4eb-_nVw-FkZzngknWVz0YPp3NsQFTM2tQdpXuUeCEdCBrIyxv0ApeGqPLDplFhgo7ZRtxQE43vasY3kdMuV26ZHAYtMcwppZV00dqqQT8j5aqrkAxwSb0bIOaGFKK2Ler6JY6frYM2rWQdhLSboRM8MlP79gt0f6hvwbEF2jFiFc</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>O'Neill, Kate A</creator><creator>Murphy, Michael Fg</creator><creator>Bunch, Kathryn J</creator><creator>Puumala, Susan E</creator><creator>Carozza, Susan E</creator><creator>Chow, Eric J</creator><creator>Mueller, Beth A</creator><creator>McLaughlin, Colleen C</creator><creator>Reynolds, Peggy</creator><creator>Vincent, Tim J</creator><creator>Von Behren, Julie</creator><creator>Spector, Logan G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20150201</creationdate><title>Infant birthweight and risk of childhood cancer: international population-based case control studies of 40 000 cases</title><author>O'Neill, Kate A ; Murphy, Michael Fg ; Bunch, Kathryn J ; Puumala, Susan E ; Carozza, Susan E ; Chow, Eric J ; Mueller, Beth A ; McLaughlin, Colleen C ; Reynolds, Peggy ; Vincent, Tim J ; Von Behren, Julie ; Spector, Logan G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-141f7f0c21442e90c81dce4b7afe3e422b048c3d29ed326cca6be1de1e5eb5d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Birth Order</topic><topic>Birth Weight</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Multiple Birth Offspring</topic><topic>Neoplasms - epidemiology</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Socioeconomic Factors</topic><topic>United Kingdom - epidemiology</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Neill, Kate A</creatorcontrib><creatorcontrib>Murphy, Michael Fg</creatorcontrib><creatorcontrib>Bunch, Kathryn J</creatorcontrib><creatorcontrib>Puumala, Susan E</creatorcontrib><creatorcontrib>Carozza, Susan E</creatorcontrib><creatorcontrib>Chow, Eric J</creatorcontrib><creatorcontrib>Mueller, Beth A</creatorcontrib><creatorcontrib>McLaughlin, Colleen C</creatorcontrib><creatorcontrib>Reynolds, Peggy</creatorcontrib><creatorcontrib>Vincent, Tim J</creatorcontrib><creatorcontrib>Von Behren, Julie</creatorcontrib><creatorcontrib>Spector, Logan G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Neill, Kate A</au><au>Murphy, Michael Fg</au><au>Bunch, Kathryn J</au><au>Puumala, Susan E</au><au>Carozza, Susan E</au><au>Chow, Eric J</au><au>Mueller, Beth A</au><au>McLaughlin, Colleen C</au><au>Reynolds, Peggy</au><au>Vincent, Tim J</au><au>Von Behren, Julie</au><au>Spector, Logan G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infant birthweight and risk of childhood cancer: international population-based case control studies of 40 000 cases</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>44</volume><issue>1</issue><spage>153</spage><epage>168</epage><pages>153-168</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><abstract>High birthweight is an established risk factor for childhood leukaemia. Its association with other childhood cancers is less clear, with studies hampered by low case numbers.
We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer. Data for 16 554 cases and 53 716 controls were obtained by linkage of birth to cancer registration records across five US states, and 23 772 cases and 33 206 controls were obtained from the UK National Registry of Childhood Tumours. US, but not UK, data were adjusted for gestational age, birth order, plurality, and maternal age and race/ethnicity.
Risk associations were found between birthweight and several childhood cancers, with strikingly similar results between datasets. Total cancer risk increased linearly with each 0.5 kg increase in birthweight in both the US [odds ratio 1.06 (95% confidence interval 1.04, 1.08)] and UK [1.06 (1.05, 1.08)] datasets. Risk was strongest for leukaemia [USA: 1.10 (1.06, 1.13), UK: 1.07 (1.04, 1.10)], tumours of the central nervous system [USA: 1.05 (1.01, 1.08), UK: 1.07 (1.04, 1.10)], renal tumours [USA: 1.17 (1.10, 1.24), UK: 1.12 (1.06, 1.19)] and soft tissue sarcomas [USA: 1.12 (1.05, 1.20), UK: 1.07 (1.00, 1.13)]. In contrast, increasing birthweight decreased the risk of hepatic tumours [USA: 0.77 (0.69, 0.85), UK: 0.79 (0.71, 0.89) per 0.5 kg increase]. Associations were also observed between high birthweight and risk of neuroblastoma, lymphomas, germ cell tumours and malignant melanomas. For some cancer subtypes, risk associations with birthweight were non-linear. We observed no association between birthweight and risk of retinoblastoma or bone tumours.
Approximately half of all childhood cancers exhibit associations with birthweight. The apparent independence from other factors indicates the importance of intrauterine growth regulation in the aetiology of these diseases.</abstract><cop>England</cop><pmid>25626438</pmid><doi>10.1093/ije/dyu265</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Birth Order Birth Weight Case-Control Studies Child Child, Preschool Female Gestational Age Humans Infant Infant, Newborn Male Multiple Birth Offspring Neoplasms - epidemiology Odds Ratio Risk Factors Sex Distribution Socioeconomic Factors United Kingdom - epidemiology United States - epidemiology |
| title | Infant birthweight and risk of childhood cancer: international population-based case control studies of 40 000 cases |
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