Diagnostic significance of cell kinetic parameters in World Health Organization type A and B3 thymomas and thymic carcinomas
Summary The prognostic importance of histologic classifications of thymic epithelial neoplasms is controversial. Evidence suggests that difficulties in reproducibility affect prognostic studies. Two thoracic pathologists independently classified 80 cases of type A or B3 thymoma and thymic carcinoma...
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| Veröffentlicht in: | Human pathology 2015-01, Vol.46 (1), p.17-25 |
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| creator | Roden, Anja C., MD Yi, Eunhee S., MD Jenkins, Sarah M Donovan, Janis L Cassivi, Stephen D., MD Garces, Yolanda I., MD Marks, Randolph S., MD Aubry, Marie-Christine, MD |
| description | Summary The prognostic importance of histologic classifications of thymic epithelial neoplasms is controversial. Evidence suggests that difficulties in reproducibility affect prognostic studies. Two thoracic pathologists independently classified 80 cases of type A or B3 thymoma and thymic carcinoma according to World Health Organization (WHO) classification. Ki-67 labeling index (LI) was used to identify cutoff points between WHO types. Recursive partitioning (Rpart) and ad hoc methods separated the data points. The pathologists agreed on type A (n = 31), type B3 (n = 21), and thymic carcinoma (n = 14). Ki-67 LI differed between types A and B3 ( P < .001) and between thymic carcinoma and type A ( P < .001) or type B3 ( P = .001). Mitotic activity differed between thymic carcinoma and type A ( P < .001) or type B3 ( P < .001). Rpart revealed Ki-67 LI greater than 14.0% only in thymic carcinoma; cases with Ki-67 LI less than 5.1% did not represent thymic carcinoma. Ad hoc analysis showed Ki-67 LI greater than or equal to 13.5% represents thymic carcinoma; only type A had Ki-67 LI less than 2%. The pathologists disagreed on histologic type in 14 cases. In 11 of 14 cases with available Ki-67, the Rpart method predicted the WHO type; in 7 of 14 cases, the ad hoc method predicted the WHO type. In conclusion, Ki-67 LI is helpful in differentiating thymic epithelial neoplasms, with Ki-67 LI less than 2% and greater than or equal to 13.5% distinguishing type A thymoma and thymic carcinoma, respectively. |
| doi_str_mv | 10.1016/j.humpath.2014.10.001 |
| format | Article |
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Evidence suggests that difficulties in reproducibility affect prognostic studies. Two thoracic pathologists independently classified 80 cases of type A or B3 thymoma and thymic carcinoma according to World Health Organization (WHO) classification. Ki-67 labeling index (LI) was used to identify cutoff points between WHO types. Recursive partitioning (Rpart) and ad hoc methods separated the data points. The pathologists agreed on type A (n = 31), type B3 (n = 21), and thymic carcinoma (n = 14). Ki-67 LI differed between types A and B3 ( P < .001) and between thymic carcinoma and type A ( P < .001) or type B3 ( P = .001). Mitotic activity differed between thymic carcinoma and type A ( P < .001) or type B3 ( P < .001). Rpart revealed Ki-67 LI greater than 14.0% only in thymic carcinoma; cases with Ki-67 LI less than 5.1% did not represent thymic carcinoma. Ad hoc analysis showed Ki-67 LI greater than or equal to 13.5% represents thymic carcinoma; only type A had Ki-67 LI less than 2%. The pathologists disagreed on histologic type in 14 cases. In 11 of 14 cases with available Ki-67, the Rpart method predicted the WHO type; in 7 of 14 cases, the ad hoc method predicted the WHO type. In conclusion, Ki-67 LI is helpful in differentiating thymic epithelial neoplasms, with Ki-67 LI less than 2% and greater than or equal to 13.5% distinguishing type A thymoma and thymic carcinoma, respectively.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2014.10.001</identifier><identifier>PMID: 25455993</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigens ; Biomarkers, Tumor - analysis ; Biopsy ; Carcinoma - pathology ; Classification ; Cloning ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen - analysis ; Kinetics ; Male ; Medical prognosis ; Metastasis ; Middle Aged ; Mitosis ; Mitotic Index ; Observer Variation ; Pathology ; Predictive Value of Tests ; Reproducibility of Results ; Statistical analysis ; Thymoma - chemistry ; Thymoma - classification ; Thymoma - pathology ; Thymus Neoplasms - chemistry ; Thymus Neoplasms - classification ; Thymus Neoplasms - pathology ; Tumors ; World Health Organization ; Young Adult</subject><ispartof>Human pathology, 2015-01, Vol.46 (1), p.17-25</ispartof><rights>Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-c8cf3d31b3ea09ace4e97f027131d72f0055d7a4832b12d8e96fa9806204df9f3</citedby><cites>FETCH-LOGICAL-c425t-c8cf3d31b3ea09ace4e97f027131d72f0055d7a4832b12d8e96fa9806204df9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25455993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roden, Anja C., MD</creatorcontrib><creatorcontrib>Yi, Eunhee S., MD</creatorcontrib><creatorcontrib>Jenkins, Sarah M</creatorcontrib><creatorcontrib>Donovan, Janis L</creatorcontrib><creatorcontrib>Cassivi, Stephen D., MD</creatorcontrib><creatorcontrib>Garces, Yolanda I., MD</creatorcontrib><creatorcontrib>Marks, Randolph S., MD</creatorcontrib><creatorcontrib>Aubry, Marie-Christine, MD</creatorcontrib><title>Diagnostic significance of cell kinetic parameters in World Health Organization type A and B3 thymomas and thymic carcinomas</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary The prognostic importance of histologic classifications of thymic epithelial neoplasms is controversial. Evidence suggests that difficulties in reproducibility affect prognostic studies. Two thoracic pathologists independently classified 80 cases of type A or B3 thymoma and thymic carcinoma according to World Health Organization (WHO) classification. Ki-67 labeling index (LI) was used to identify cutoff points between WHO types. Recursive partitioning (Rpart) and ad hoc methods separated the data points. The pathologists agreed on type A (n = 31), type B3 (n = 21), and thymic carcinoma (n = 14). Ki-67 LI differed between types A and B3 ( P < .001) and between thymic carcinoma and type A ( P < .001) or type B3 ( P = .001). Mitotic activity differed between thymic carcinoma and type A ( P < .001) or type B3 ( P < .001). Rpart revealed Ki-67 LI greater than 14.0% only in thymic carcinoma; cases with Ki-67 LI less than 5.1% did not represent thymic carcinoma. Ad hoc analysis showed Ki-67 LI greater than or equal to 13.5% represents thymic carcinoma; only type A had Ki-67 LI less than 2%. The pathologists disagreed on histologic type in 14 cases. In 11 of 14 cases with available Ki-67, the Rpart method predicted the WHO type; in 7 of 14 cases, the ad hoc method predicted the WHO type. In conclusion, Ki-67 LI is helpful in differentiating thymic epithelial neoplasms, with Ki-67 LI less than 2% and greater than or equal to 13.5% distinguishing type A thymoma and thymic carcinoma, respectively.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy</subject><subject>Carcinoma - pathology</subject><subject>Classification</subject><subject>Cloning</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - analysis</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mitosis</subject><subject>Mitotic Index</subject><subject>Observer Variation</subject><subject>Pathology</subject><subject>Predictive Value of Tests</subject><subject>Reproducibility of Results</subject><subject>Statistical analysis</subject><subject>Thymoma - chemistry</subject><subject>Thymoma - classification</subject><subject>Thymoma - pathology</subject><subject>Thymus Neoplasms - chemistry</subject><subject>Thymus Neoplasms - classification</subject><subject>Thymus Neoplasms - pathology</subject><subject>Tumors</subject><subject>World Health Organization</subject><subject>Young Adult</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EokvhJ4AsceGSxZ9JfEEq5aNIlXoAxNHyOuNdbxMn2AnSVv3x2OwCEhdO4xk_M5qZdxB6TsmaElq_3q93yzCZebdmhIocWxNCH6AVlZxVLVfsIVoRIuqqpU1zhp6ktM8AlUI-RmcsG6kUX6H7d95sw5hmb3Hy2-CdtyZYwKPDFvoe3_oA5XMy0QwwQ0zYB_xtjH2Hr8D08w7fxK0J_s7Mfgx4PkyAL7AJHX7L8bw7DONg0i-_OLmSNdH6UKJP0SNn-gTPTvYcff3w_svlVXV98_HT5cV1ZQWTc2Vb63jH6YaDIcpYEKAaR1hDOe0a5giRsmuMaDnbUNa1oGpnVEtqRkTnlOPn6NWx7hTH7wukWQ8-lelMgHFJmjZ5ha3gov4_WvNGSi5altGX_6D7cYkhD1IoIVTLKc-UPFI2jilFcHqKfjDxoCnRRUm91ycldVGyhLNQOe_FqfqyGaD7k_Vbugy8OQKQN_fDQ9S29yGr19_CAdLfXnRimujP5RjKLVCRX6RR_CfsPLD6</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Roden, Anja C., MD</creator><creator>Yi, Eunhee S., MD</creator><creator>Jenkins, Sarah M</creator><creator>Donovan, Janis L</creator><creator>Cassivi, Stephen D., MD</creator><creator>Garces, Yolanda I., MD</creator><creator>Marks, Randolph S., MD</creator><creator>Aubry, Marie-Christine, MD</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20150101</creationdate><title>Diagnostic significance of cell kinetic parameters in World Health Organization type A and B3 thymomas and thymic carcinomas</title><author>Roden, Anja C., MD ; Yi, Eunhee S., MD ; Jenkins, Sarah M ; Donovan, Janis L ; Cassivi, Stephen D., MD ; Garces, Yolanda I., MD ; Marks, Randolph S., MD ; Aubry, Marie-Christine, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-c8cf3d31b3ea09ace4e97f027131d72f0055d7a4832b12d8e96fa9806204df9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biopsy</topic><topic>Carcinoma - pathology</topic><topic>Classification</topic><topic>Cloning</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - analysis</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mitosis</topic><topic>Mitotic Index</topic><topic>Observer Variation</topic><topic>Pathology</topic><topic>Predictive Value of Tests</topic><topic>Reproducibility of Results</topic><topic>Statistical analysis</topic><topic>Thymoma - chemistry</topic><topic>Thymoma - classification</topic><topic>Thymoma - pathology</topic><topic>Thymus Neoplasms - chemistry</topic><topic>Thymus Neoplasms - classification</topic><topic>Thymus Neoplasms - pathology</topic><topic>Tumors</topic><topic>World Health Organization</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roden, Anja C., MD</creatorcontrib><creatorcontrib>Yi, Eunhee S., MD</creatorcontrib><creatorcontrib>Jenkins, Sarah M</creatorcontrib><creatorcontrib>Donovan, Janis L</creatorcontrib><creatorcontrib>Cassivi, Stephen D., MD</creatorcontrib><creatorcontrib>Garces, Yolanda I., MD</creatorcontrib><creatorcontrib>Marks, Randolph S., MD</creatorcontrib><creatorcontrib>Aubry, Marie-Christine, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roden, Anja C., MD</au><au>Yi, Eunhee S., MD</au><au>Jenkins, Sarah M</au><au>Donovan, Janis L</au><au>Cassivi, Stephen D., MD</au><au>Garces, Yolanda I., MD</au><au>Marks, Randolph S., MD</au><au>Aubry, Marie-Christine, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic significance of cell kinetic parameters in World Health Organization type A and B3 thymomas and thymic carcinomas</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>46</volume><issue>1</issue><spage>17</spage><epage>25</epage><pages>17-25</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><abstract>Summary The prognostic importance of histologic classifications of thymic epithelial neoplasms is controversial. Evidence suggests that difficulties in reproducibility affect prognostic studies. Two thoracic pathologists independently classified 80 cases of type A or B3 thymoma and thymic carcinoma according to World Health Organization (WHO) classification. Ki-67 labeling index (LI) was used to identify cutoff points between WHO types. Recursive partitioning (Rpart) and ad hoc methods separated the data points. The pathologists agreed on type A (n = 31), type B3 (n = 21), and thymic carcinoma (n = 14). Ki-67 LI differed between types A and B3 ( P < .001) and between thymic carcinoma and type A ( P < .001) or type B3 ( P = .001). Mitotic activity differed between thymic carcinoma and type A ( P < .001) or type B3 ( P < .001). Rpart revealed Ki-67 LI greater than 14.0% only in thymic carcinoma; cases with Ki-67 LI less than 5.1% did not represent thymic carcinoma. Ad hoc analysis showed Ki-67 LI greater than or equal to 13.5% represents thymic carcinoma; only type A had Ki-67 LI less than 2%. The pathologists disagreed on histologic type in 14 cases. In 11 of 14 cases with available Ki-67, the Rpart method predicted the WHO type; in 7 of 14 cases, the ad hoc method predicted the WHO type. In conclusion, Ki-67 LI is helpful in differentiating thymic epithelial neoplasms, with Ki-67 LI less than 2% and greater than or equal to 13.5% distinguishing type A thymoma and thymic carcinoma, respectively.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>25455993</pmid><doi>10.1016/j.humpath.2014.10.001</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antigens Biomarkers, Tumor - analysis Biopsy Carcinoma - pathology Classification Cloning Diagnosis, Differential Female Humans Immunohistochemistry Ki-67 Antigen - analysis Kinetics Male Medical prognosis Metastasis Middle Aged Mitosis Mitotic Index Observer Variation Pathology Predictive Value of Tests Reproducibility of Results Statistical analysis Thymoma - chemistry Thymoma - classification Thymoma - pathology Thymus Neoplasms - chemistry Thymus Neoplasms - classification Thymus Neoplasms - pathology Tumors World Health Organization Young Adult |
| title | Diagnostic significance of cell kinetic parameters in World Health Organization type A and B3 thymomas and thymic carcinomas |
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