Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran
There is no published data on association of HLA class II alleles with clearance or persistence after acute hepatitis C virus (HCV) infection in patients from Iran. HLA DRB1, DQA1, and DQB1 alleles were determined using polymerase chain reaction amplification with sequence specific primers (PCR‐SSP)...
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| Veröffentlicht in: | Journal of medical virology 2015-09, Vol.87 (9), p.1565-1572 |
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| description | There is no published data on association of HLA class II alleles with clearance or persistence after acute hepatitis C virus (HCV) infection in patients from Iran. HLA DRB1, DQA1, and DQB1 alleles were determined using polymerase chain reaction amplification with sequence specific primers (PCR‐SSP) on a total of 117 thalassemia patients (63 with chronic infection, and 54 with viral clearance) and 120 healthy controls. HLA‐DRB1*0301 and DQA1*0501 alleles were found significantly present in patients with HCV clearance compared to those with chronic infection (P = 0.03 and P = 0.0007, respectively). By contrast, DRB1*0701, DQA1*0201, and DQB1*0602 alleles occurred significantly in those with chronic infection compared to those with viral clearance (P = 0.004, P = 0.007, and P = 0.02, respectively). As compared to the controls, DRB1*0301, DRB1*11, DQA1*0501, and DQB1*0301 alleles showed a significant decrease in chronic patients (P = 0.002, P = 0.001, P = 0.0001, and P = 0.0004, respectively). Furthermore, the haplotype frequencies of DRB1*0301, DQA1*0501, DQB1*0201, and DRB1*1101, DQA1*0501, DQB1*0301 were found significantly higher (P = 0.004 and P = 0.04, respectively) in patients with HCV clearance than those with chronic infection. By contrast, the haplotype DRB1*0701, DQA1*0201, DQB1*0201 occurred more frequently (P = 0.02) in those with chronic infection compared with those with viral clearance. These findings suggest that particular HLA alleles and related haplotypes may have an influence on the outcome of HCV infection among the Iranian patients. Some of the HLA alleles found in the Iranian patients are different from those reported elsewhere, suggesting that the immunogenetic makeup for HCV clearance or persistence may vary based on the ethnicity. J. Med. Virol. 87:1565–1572, 2015. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.24211 |
| format | Article |
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HLA DRB1, DQA1, and DQB1 alleles were determined using polymerase chain reaction amplification with sequence specific primers (PCR‐SSP) on a total of 117 thalassemia patients (63 with chronic infection, and 54 with viral clearance) and 120 healthy controls. HLA‐DRB1*0301 and DQA1*0501 alleles were found significantly present in patients with HCV clearance compared to those with chronic infection (P = 0.03 and P = 0.0007, respectively). By contrast, DRB1*0701, DQA1*0201, and DQB1*0602 alleles occurred significantly in those with chronic infection compared to those with viral clearance (P = 0.004, P = 0.007, and P = 0.02, respectively). As compared to the controls, DRB1*0301, DRB1*11, DQA1*0501, and DQB1*0301 alleles showed a significant decrease in chronic patients (P = 0.002, P = 0.001, P = 0.0001, and P = 0.0004, respectively). Furthermore, the haplotype frequencies of DRB1*0301, DQA1*0501, DQB1*0201, and DRB1*1101, DQA1*0501, DQB1*0301 were found significantly higher (P = 0.004 and P = 0.04, respectively) in patients with HCV clearance than those with chronic infection. By contrast, the haplotype DRB1*0701, DQA1*0201, DQB1*0201 occurred more frequently (P = 0.02) in those with chronic infection compared with those with viral clearance. These findings suggest that particular HLA alleles and related haplotypes may have an influence on the outcome of HCV infection among the Iranian patients. Some of the HLA alleles found in the Iranian patients are different from those reported elsewhere, suggesting that the immunogenetic makeup for HCV clearance or persistence may vary based on the ethnicity. J. Med. Virol. 87:1565–1572, 2015. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.24211</identifier><identifier>PMID: 25970464</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Alleles ; Child ; Epidemiology ; Ethnicity ; Female ; Gene Frequency ; Genes, MHC Class II ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; HCV clearance ; HCV persistence ; Healthy Volunteers ; Hepacivirus - physiology ; Hepatitis ; Hepatitis C - ethnology ; Hepatitis C - genetics ; Hepatitis C - immunology ; Hepatitis C - virology ; Hepatitis C virus ; Hepatitis C, Chronic - ethnology ; Hepatitis C, Chronic - virology ; HLA class II ; HLA-DQ alpha-Chains - genetics ; HLA-DQ Antigens - genetics ; HLA-DQ beta-Chains - genetics ; HLA-DRB1 Chains - genetics ; Humans ; Immunology ; Iran - epidemiology ; Male ; Middle Aged ; Thalassemia - complications ; Thalassemia - epidemiology ; Thalassemia - genetics ; thalassemia patients ; Virology ; Virus Shedding ; Young Adult</subject><ispartof>Journal of medical virology, 2015-09, Vol.87 (9), p.1565-1572</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4601-42a73bce047ca48696d92761772c9148973d65d9fbc0b9317e18e8014970fed43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.24211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.24211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25970464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samimi-Rad, Katayoun</creatorcontrib><creatorcontrib>Sadeghi, Farzin</creatorcontrib><creatorcontrib>Amirzargar, Aliakbar</creatorcontrib><creatorcontrib>Eshraghian, Mohamad Reza</creatorcontrib><creatorcontrib>Alavian, Seyed-Moayed</creatorcontrib><creatorcontrib>Rahimnia, Ramin</creatorcontrib><title>Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>There is no published data on association of HLA class II alleles with clearance or persistence after acute hepatitis C virus (HCV) infection in patients from Iran. HLA DRB1, DQA1, and DQB1 alleles were determined using polymerase chain reaction amplification with sequence specific primers (PCR‐SSP) on a total of 117 thalassemia patients (63 with chronic infection, and 54 with viral clearance) and 120 healthy controls. HLA‐DRB1*0301 and DQA1*0501 alleles were found significantly present in patients with HCV clearance compared to those with chronic infection (P = 0.03 and P = 0.0007, respectively). By contrast, DRB1*0701, DQA1*0201, and DQB1*0602 alleles occurred significantly in those with chronic infection compared to those with viral clearance (P = 0.004, P = 0.007, and P = 0.02, respectively). As compared to the controls, DRB1*0301, DRB1*11, DQA1*0501, and DQB1*0301 alleles showed a significant decrease in chronic patients (P = 0.002, P = 0.001, P = 0.0001, and P = 0.0004, respectively). Furthermore, the haplotype frequencies of DRB1*0301, DQA1*0501, DQB1*0201, and DRB1*1101, DQA1*0501, DQB1*0301 were found significantly higher (P = 0.004 and P = 0.04, respectively) in patients with HCV clearance than those with chronic infection. By contrast, the haplotype DRB1*0701, DQA1*0201, DQB1*0201 occurred more frequently (P = 0.02) in those with chronic infection compared with those with viral clearance. These findings suggest that particular HLA alleles and related haplotypes may have an influence on the outcome of HCV infection among the Iranian patients. Some of the HLA alleles found in the Iranian patients are different from those reported elsewhere, suggesting that the immunogenetic makeup for HCV clearance or persistence may vary based on the ethnicity. J. Med. Virol. 87:1565–1572, 2015. © 2015 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Child</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes, MHC Class II</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>HCV clearance</subject><subject>HCV persistence</subject><subject>Healthy Volunteers</subject><subject>Hepacivirus - physiology</subject><subject>Hepatitis</subject><subject>Hepatitis C - ethnology</subject><subject>Hepatitis C - genetics</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - ethnology</subject><subject>Hepatitis C, Chronic - virology</subject><subject>HLA class II</subject><subject>HLA-DQ alpha-Chains - genetics</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ beta-Chains - genetics</subject><subject>HLA-DRB1 Chains - genetics</subject><subject>Humans</subject><subject>Immunology</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Thalassemia - complications</subject><subject>Thalassemia - epidemiology</subject><subject>Thalassemia - genetics</subject><subject>thalassemia patients</subject><subject>Virology</subject><subject>Virus Shedding</subject><subject>Young Adult</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0EoqGw4AWQJTZspr32eOzxMoqgDQo_i9KibizHc0dxmJ_Unknbt6-nKV2wYWVb_r4rnXsIec_ghAHw0227P-GCM_aCzBhomWlQ7CWZARMyk5IVR-RNjFsAKDXnr8kRL7QCIcWM7Ocx9s7bwfcd7Wt6vppT19gY6XJJbdNgg5He-mFDN7hL1OAjXdC9D2NMHNpgO4fUdhXdYYg-Dji9fUeHjZ3GYOstnUTshkjr0Ld0mZy35FVtm4jvns5j8uvL54vFebb6cbZczFeZExJYJrhV-dohCOWsKKWWleZKMqW400yUWuWVLCpdrx2sdc4UshLLFDvFq7ES-TH5dJi7C_3NiHEwrY8Om8Z22I_RMJXgknNd_B-VWnGmOOiEfvwH3fZj6FKQiZIghNSQqA9P1LhusTK74Fsb7s3f5Sfg9ADc-gbvn_8ZmKlVk1o1j62ar98uHy_JyA7GtOi7Z8OGP0aqXBXm6vuZWVz_vlDXV5fmZ_4A4LCh2Q</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Samimi-Rad, Katayoun</creator><creator>Sadeghi, Farzin</creator><creator>Amirzargar, Aliakbar</creator><creator>Eshraghian, Mohamad Reza</creator><creator>Alavian, Seyed-Moayed</creator><creator>Rahimnia, Ramin</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran</title><author>Samimi-Rad, Katayoun ; 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Med. Virol</addtitle><date>2015-09</date><risdate>2015</risdate><volume>87</volume><issue>9</issue><spage>1565</spage><epage>1572</epage><pages>1565-1572</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>There is no published data on association of HLA class II alleles with clearance or persistence after acute hepatitis C virus (HCV) infection in patients from Iran. HLA DRB1, DQA1, and DQB1 alleles were determined using polymerase chain reaction amplification with sequence specific primers (PCR‐SSP) on a total of 117 thalassemia patients (63 with chronic infection, and 54 with viral clearance) and 120 healthy controls. HLA‐DRB1*0301 and DQA1*0501 alleles were found significantly present in patients with HCV clearance compared to those with chronic infection (P = 0.03 and P = 0.0007, respectively). By contrast, DRB1*0701, DQA1*0201, and DQB1*0602 alleles occurred significantly in those with chronic infection compared to those with viral clearance (P = 0.004, P = 0.007, and P = 0.02, respectively). As compared to the controls, DRB1*0301, DRB1*11, DQA1*0501, and DQB1*0301 alleles showed a significant decrease in chronic patients (P = 0.002, P = 0.001, P = 0.0001, and P = 0.0004, respectively). Furthermore, the haplotype frequencies of DRB1*0301, DQA1*0501, DQB1*0201, and DRB1*1101, DQA1*0501, DQB1*0301 were found significantly higher (P = 0.004 and P = 0.04, respectively) in patients with HCV clearance than those with chronic infection. By contrast, the haplotype DRB1*0701, DQA1*0201, DQB1*0201 occurred more frequently (P = 0.02) in those with chronic infection compared with those with viral clearance. These findings suggest that particular HLA alleles and related haplotypes may have an influence on the outcome of HCV infection among the Iranian patients. Some of the HLA alleles found in the Iranian patients are different from those reported elsewhere, suggesting that the immunogenetic makeup for HCV clearance or persistence may vary based on the ethnicity. J. Med. Virol. 87:1565–1572, 2015. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25970464</pmid><doi>10.1002/jmv.24211</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Alleles Child Epidemiology Ethnicity Female Gene Frequency Genes, MHC Class II Genetic Association Studies Genetic Predisposition to Disease Genotype Haplotypes HCV clearance HCV persistence Healthy Volunteers Hepacivirus - physiology Hepatitis Hepatitis C - ethnology Hepatitis C - genetics Hepatitis C - immunology Hepatitis C - virology Hepatitis C virus Hepatitis C, Chronic - ethnology Hepatitis C, Chronic - virology HLA class II HLA-DQ alpha-Chains - genetics HLA-DQ Antigens - genetics HLA-DQ beta-Chains - genetics HLA-DRB1 Chains - genetics Humans Immunology Iran - epidemiology Male Middle Aged Thalassemia - complications Thalassemia - epidemiology Thalassemia - genetics thalassemia patients Virology Virus Shedding Young Adult |
| title | Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran |
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