Evaluation of the antibacterial and antibiofilm activities of novel CRAMP-vancomycin conjugates with diverse linkers

We report the design, synthesis and antibacterial activity analysis of conjugates of vancomycin and cathelicidin-related antimicrobial peptides (CRAMP). Vancomycin inhibits the nascent peptidoglycan synthesis and is highly active against Gram-positive bacteria, whereas Gram-negative bacteria are gen...

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Veröffentlicht in:	Organic & biomolecular chemistry 2015-07, Vol.13 (27), p.7477-7486
Hauptverfasser:	Mishra, Nigam M, Briers, Yves, Lamberigts, Chris, Steenackers, Hans, Robijns, Stijn, Landuyt, Bart, Vanderleyden, Jos, Schoofs, Liliane, Lavigne, Rob, Luyten, Walter, Van der Eycken, Erik V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides Bacteria - drug effects Bacteria - growth & development Biofilms - drug effects Biofilms - growth & development Cathelicidins - chemistry Cathelicidins - pharmacology Chromatography, Liquid Hydrophobic and Hydrophilic Interactions Isomerism Mass Spectrometry Microbial Sensitivity Tests Microscopy, Atomic Force Molecular Sequence Data Vancomycin - chemistry Vancomycin - pharmacology
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