Gap Junctions Enhance the Antiproliferative Effect of MicroRNA-124-3p in Glioblastoma Cells

MicroRNA (miRNA) holds promise as a novel therapeutic tool for cancer treatment. However, the transfection efficiency of current delivery systems represents a bottleneck for clinical applications. Here, we demonstrate that gap junctions mediate an augmentative effect on the antiproliferation mediate...

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Veröffentlicht in:	Journal of cellular physiology 2015-10, Vol.230 (10), p.2476-2488
Hauptverfasser:	Suzhi, Zhang, Liang, Tao, Yuexia, Peng, Lucy, Liu, Xiaoting, Hong, Yuan, Zhang, Qin, Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cell Proliferation - physiology Coculture Techniques Gap Junctions - metabolism Gene Expression Regulation, Neoplastic - genetics Glioblastoma - genetics Glioblastoma - metabolism Humans Mice MicroRNAs - genetics MicroRNAs - metabolism
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