Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling

Crude extract of Rheum palmatum L. (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the anti‐metastasis effects of CERP on LS1034 human colorectal cancer cells in vitro and examined potential mechanisms of its effects. CERP signif...

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Veröffentlicht in:	Environmental toxicology 2015-07, Vol.30 (7), p.852-863
Hauptverfasser:	Ma, Yi‐Shih, Hsiao, Yu‐Ping, Lin, Ju‐Hwa, Hsu, Shu‐Chun, Chueh, Fu‐Shin, Weng, Shu‐Wen, Lai, Kuang‐Chi, Lin, Jaung‐Geng, Chung, Jing‐Gung
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Culture Techniques Cell Line, Tumor cell movement Cell Movement - drug effects Cell Survival - drug effects Colonic Neoplasms - metabolism Colonic Neoplasms - pathology colorectal neoplasms crude extract of Rheum palmatum L cyclins human colon cancer LS1034 cells Humans inducible nitric oxide synthase invasion MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism matrix metalloproteinases migration mitogen-activated protein kinase neoplasm cells Plant Extracts - chemistry Plant Extracts - pharmacology protein kinase C Rheum Rheum - chemistry Rheum - metabolism Rheum palmatum rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - metabolism transcription factor NF-kappa B Transcription Factor RelA - metabolism vascular endothelial growth factors Wound Healing - drug effects
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