Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling
Crude extract of Rheum palmatum L. (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the anti‐metastasis effects of CERP on LS1034 human colorectal cancer cells in vitro and examined potential mechanisms of its effects. CERP signif...
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| Veröffentlicht in: | Environmental toxicology 2015-07, Vol.30 (7), p.852-863 |
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| creator | Ma, Yi‐Shih Hsiao, Yu‐Ping Lin, Ju‐Hwa Hsu, Shu‐Chun Chueh, Fu‐Shin Weng, Shu‐Wen Lai, Kuang‐Chi Lin, Jaung‐Geng Chung, Jing‐Gung |
| description | Crude extract of Rheum palmatum L. (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the anti‐metastasis effects of CERP on LS1034 human colorectal cancer cells in vitro and examined potential mechanisms of its effects. CERP significantly inhibited cell migration and invasion of LS1034 cells. We also found that CERP inhibited protein levels of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9), and cytosolic NF‐kB p65, RHO A, ROCK 1. Furthermore, we found CERP inhibited protein levels of GRB2, SOS1, MKK7, FAK, Rho A, ROCK 1, VEGF, PKC, AKT, phosphor‐AKT (Thr308), Cyclin D, iNOS, COX2, NF‐kB p65, p‐ERK1/2, p‐JNK1/2, p‐p38, p‐c‐jun, MMP‐2, MMP‐9, MMP‐1, MMP‐7, MMP‐10, UPA and increased the protein level of Ras in LS1034 cells. In conclusion, our results suggest that CERP may be used as a novel anti‐metastasis agent for the treatment of human colon cancer cells. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 852–863, 2015. |
| doi_str_mv | 10.1002/tox.21962 |
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(CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the anti‐metastasis effects of CERP on LS1034 human colorectal cancer cells in vitro and examined potential mechanisms of its effects. CERP significantly inhibited cell migration and invasion of LS1034 cells. We also found that CERP inhibited protein levels of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9), and cytosolic NF‐kB p65, RHO A, ROCK 1. Furthermore, we found CERP inhibited protein levels of GRB2, SOS1, MKK7, FAK, Rho A, ROCK 1, VEGF, PKC, AKT, phosphor‐AKT (Thr308), Cyclin D, iNOS, COX2, NF‐kB p65, p‐ERK1/2, p‐JNK1/2, p‐p38, p‐c‐jun, MMP‐2, MMP‐9, MMP‐1, MMP‐7, MMP‐10, UPA and increased the protein level of Ras in LS1034 cells. In conclusion, our results suggest that CERP may be used as a novel anti‐metastasis agent for the treatment of human colon cancer cells. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 852–863, 2015.</description><identifier>ISSN: 1520-4081</identifier><identifier>EISSN: 1522-7278</identifier><identifier>DOI: 10.1002/tox.21962</identifier><identifier>PMID: 24497447</identifier><identifier>CODEN: ETOXFH</identifier><language>eng</language><publisher>United States: John Wiley & Sons</publisher><subject>Cell Culture Techniques ; Cell Line, Tumor ; cell movement ; Cell Movement - drug effects ; Cell Survival - drug effects ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; colorectal neoplasms ; crude extract of Rheum palmatum L ; cyclins ; human colon cancer LS1034 cells ; Humans ; inducible nitric oxide synthase ; invasion ; MAP Kinase Signaling System - drug effects ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - metabolism ; matrix metalloproteinases ; migration ; mitogen-activated protein kinase ; neoplasm cells ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; protein kinase C ; Rheum ; Rheum - chemistry ; Rheum - metabolism ; Rheum palmatum ; rho-Associated Kinases - metabolism ; rhoA GTP-Binding Protein - metabolism ; transcription factor NF-kappa B ; Transcription Factor RelA - metabolism ; vascular endothelial growth factors ; Wound Healing - drug effects</subject><ispartof>Environmental toxicology, 2015-07, Vol.30 (7), p.852-863</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5552-40bf0d092f0c0e916df83804000747ce30de5c496630e33ee9b7f9acd78e23103</citedby><cites>FETCH-LOGICAL-c5552-40bf0d092f0c0e916df83804000747ce30de5c496630e33ee9b7f9acd78e23103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftox.21962$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftox.21962$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24497447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Yi‐Shih</creatorcontrib><creatorcontrib>Hsiao, Yu‐Ping</creatorcontrib><creatorcontrib>Lin, Ju‐Hwa</creatorcontrib><creatorcontrib>Hsu, Shu‐Chun</creatorcontrib><creatorcontrib>Chueh, Fu‐Shin</creatorcontrib><creatorcontrib>Weng, Shu‐Wen</creatorcontrib><creatorcontrib>Lai, Kuang‐Chi</creatorcontrib><creatorcontrib>Lin, Jaung‐Geng</creatorcontrib><creatorcontrib>Chung, Jing‐Gung</creatorcontrib><title>Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling</title><title>Environmental toxicology</title><addtitle>Environ. Toxicol</addtitle><description>Crude extract of Rheum palmatum L. (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the anti‐metastasis effects of CERP on LS1034 human colorectal cancer cells in vitro and examined potential mechanisms of its effects. CERP significantly inhibited cell migration and invasion of LS1034 cells. We also found that CERP inhibited protein levels of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9), and cytosolic NF‐kB p65, RHO A, ROCK 1. Furthermore, we found CERP inhibited protein levels of GRB2, SOS1, MKK7, FAK, Rho A, ROCK 1, VEGF, PKC, AKT, phosphor‐AKT (Thr308), Cyclin D, iNOS, COX2, NF‐kB p65, p‐ERK1/2, p‐JNK1/2, p‐p38, p‐c‐jun, MMP‐2, MMP‐9, MMP‐1, MMP‐7, MMP‐10, UPA and increased the protein level of Ras in LS1034 cells. In conclusion, our results suggest that CERP may be used as a novel anti‐metastasis agent for the treatment of human colon cancer cells. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 852–863, 2015.</description><subject>Cell Culture Techniques</subject><subject>Cell Line, Tumor</subject><subject>cell movement</subject><subject>Cell Movement - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>colorectal neoplasms</subject><subject>crude extract of Rheum palmatum L</subject><subject>cyclins</subject><subject>human colon cancer LS1034 cells</subject><subject>Humans</subject><subject>inducible nitric oxide synthase</subject><subject>invasion</subject><subject>MAP Kinase Signaling System - drug effects</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>matrix metalloproteinases</subject><subject>migration</subject><subject>mitogen-activated protein kinase</subject><subject>neoplasm cells</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>protein kinase C</subject><subject>Rheum</subject><subject>Rheum - chemistry</subject><subject>Rheum - metabolism</subject><subject>Rheum palmatum</subject><subject>rho-Associated Kinases - metabolism</subject><subject>rhoA GTP-Binding Protein - metabolism</subject><subject>transcription factor NF-kappa B</subject><subject>Transcription Factor RelA - metabolism</subject><subject>vascular endothelial growth factors</subject><subject>Wound Healing - drug effects</subject><issn>1520-4081</issn><issn>1522-7278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9uEzEQxlcIREvhwAuAJS5wSOM_u-v1sYqgIAJFtBVVL5bjnU1cdtfB9kJy4xF4G96HJ2HSJD0gcfHYo998M-Mvy54yeswo5ePkV8ecqZLfyw5ZwflIclndv73TUU4rdpA9ivGGUqrKonyYHfA8VzLP5WH2exKGGgisUjA2Ed-QzwsYOrI0bWcSXqbE9Qs3cymSzs2DSc73xPQ1pr-buHlgzfScUZGTxdCZnljfYtaa3kIgFto2EpSOJC2CH-YLjLDX3JVjp-BWpINk2tYvg0_gehPhz89ffIyHIrM1-XDy6T2Jbt6b1vXzx9mDxrQRnuziUXb55vXF5O1oenb6bnIyHdmiKDguP2toTRVvqKWgWFk3lahojl8hc2lB0BoKm6uyFBSEAFAz2Shja1kBF7jUUfZyq4tTfRsgJt25uFnK9OCHqJmkLK_QBIXoi3_QGz8EHBepslKVkpJxpF5tKRt8jAEavQyuM2GtGdUbNzW6qW_dRPbZTnGYdVDfkXv7EBhvgR-uhfX_lfTF2dVecrStcDHB6q7ChK-6lEIW-svHU30t5FVFryu96fB8yzfGazMPLurLc05ZgfqMU1GIv1pQxCs</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Ma, Yi‐Shih</creator><creator>Hsiao, Yu‐Ping</creator><creator>Lin, Ju‐Hwa</creator><creator>Hsu, Shu‐Chun</creator><creator>Chueh, Fu‐Shin</creator><creator>Weng, Shu‐Wen</creator><creator>Lai, Kuang‐Chi</creator><creator>Lin, Jaung‐Geng</creator><creator>Chung, Jing‐Gung</creator><general>John Wiley & Sons</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>SOI</scope><scope>7TV</scope></search><sort><creationdate>201507</creationdate><title>Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling</title><author>Ma, Yi‐Shih ; Hsiao, Yu‐Ping ; Lin, Ju‐Hwa ; Hsu, Shu‐Chun ; Chueh, Fu‐Shin ; Weng, Shu‐Wen ; Lai, Kuang‐Chi ; Lin, Jaung‐Geng ; Chung, Jing‐Gung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5552-40bf0d092f0c0e916df83804000747ce30de5c496630e33ee9b7f9acd78e23103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cell Culture Techniques</topic><topic>Cell Line, Tumor</topic><topic>cell movement</topic><topic>Cell Movement - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>colorectal neoplasms</topic><topic>crude extract of Rheum palmatum L</topic><topic>cyclins</topic><topic>human colon cancer LS1034 cells</topic><topic>Humans</topic><topic>inducible nitric oxide synthase</topic><topic>invasion</topic><topic>MAP Kinase Signaling System - drug effects</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>matrix metalloproteinases</topic><topic>migration</topic><topic>mitogen-activated protein kinase</topic><topic>neoplasm cells</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>protein kinase C</topic><topic>Rheum</topic><topic>Rheum - chemistry</topic><topic>Rheum - metabolism</topic><topic>Rheum palmatum</topic><topic>rho-Associated Kinases - metabolism</topic><topic>rhoA GTP-Binding Protein - metabolism</topic><topic>transcription factor NF-kappa B</topic><topic>Transcription Factor RelA - metabolism</topic><topic>vascular endothelial growth factors</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Yi‐Shih</creatorcontrib><creatorcontrib>Hsiao, Yu‐Ping</creatorcontrib><creatorcontrib>Lin, Ju‐Hwa</creatorcontrib><creatorcontrib>Hsu, Shu‐Chun</creatorcontrib><creatorcontrib>Chueh, Fu‐Shin</creatorcontrib><creatorcontrib>Weng, Shu‐Wen</creatorcontrib><creatorcontrib>Lai, Kuang‐Chi</creatorcontrib><creatorcontrib>Lin, Jaung‐Geng</creatorcontrib><creatorcontrib>Chung, Jing‐Gung</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><jtitle>Environmental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Yi‐Shih</au><au>Hsiao, Yu‐Ping</au><au>Lin, Ju‐Hwa</au><au>Hsu, Shu‐Chun</au><au>Chueh, Fu‐Shin</au><au>Weng, Shu‐Wen</au><au>Lai, Kuang‐Chi</au><au>Lin, Jaung‐Geng</au><au>Chung, Jing‐Gung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling</atitle><jtitle>Environmental toxicology</jtitle><addtitle>Environ. Toxicol</addtitle><date>2015-07</date><risdate>2015</risdate><volume>30</volume><issue>7</issue><spage>852</spage><epage>863</epage><pages>852-863</pages><issn>1520-4081</issn><eissn>1522-7278</eissn><coden>ETOXFH</coden><abstract>Crude extract of Rheum palmatum L. (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the anti‐metastasis effects of CERP on LS1034 human colorectal cancer cells in vitro and examined potential mechanisms of its effects. CERP significantly inhibited cell migration and invasion of LS1034 cells. We also found that CERP inhibited protein levels of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9), and cytosolic NF‐kB p65, RHO A, ROCK 1. Furthermore, we found CERP inhibited protein levels of GRB2, SOS1, MKK7, FAK, Rho A, ROCK 1, VEGF, PKC, AKT, phosphor‐AKT (Thr308), Cyclin D, iNOS, COX2, NF‐kB p65, p‐ERK1/2, p‐JNK1/2, p‐p38, p‐c‐jun, MMP‐2, MMP‐9, MMP‐1, MMP‐7, MMP‐10, UPA and increased the protein level of Ras in LS1034 cells. In conclusion, our results suggest that CERP may be used as a novel anti‐metastasis agent for the treatment of human colon cancer cells. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 852–863, 2015.</abstract><cop>United States</cop><pub>John Wiley & Sons</pub><pmid>24497447</pmid><doi>10.1002/tox.21962</doi><tpages>12</tpages></addata></record> |
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| subjects | Cell Culture Techniques Cell Line, Tumor cell movement Cell Movement - drug effects Cell Survival - drug effects Colonic Neoplasms - metabolism Colonic Neoplasms - pathology colorectal neoplasms crude extract of Rheum palmatum L cyclins human colon cancer LS1034 cells Humans inducible nitric oxide synthase invasion MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism matrix metalloproteinases migration mitogen-activated protein kinase neoplasm cells Plant Extracts - chemistry Plant Extracts - pharmacology protein kinase C Rheum Rheum - chemistry Rheum - metabolism Rheum palmatum rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - metabolism transcription factor NF-kappa B Transcription Factor RelA - metabolism vascular endothelial growth factors Wound Healing - drug effects |
| title | Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling |
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