The genetic basis of intradural spinal tumors and its impact on clinical treatment

Genetic alterations in the cells of intradural spinal tumors can have a significant impact on the treatment options, counseling, and prognosis for patients. Although surgery is the primary therapy for most intradural tumors, radiochemothera-peutic modalities and targeted interventions play an ever-e...

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Veröffentlicht in:Neurosurgical focus 2015-08, Vol.39 (2), p.E3-E3
Hauptverfasser: Karsy, Michael, Guan, Jian, Sivakumar, Walavan, Neil, Jayson A, Schmidt, Meic H, Mahan, Mark A
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container_issue 2
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container_title Neurosurgical focus
container_volume 39
creator Karsy, Michael
Guan, Jian
Sivakumar, Walavan
Neil, Jayson A
Schmidt, Meic H
Mahan, Mark A
description Genetic alterations in the cells of intradural spinal tumors can have a significant impact on the treatment options, counseling, and prognosis for patients. Although surgery is the primary therapy for most intradural tumors, radiochemothera-peutic modalities and targeted interventions play an ever-evolving role in treating aggressive cancers and in addressing cancer recurrence in long-term survivors. Recent studies have helped delineate specific genetic and molecular differences between intradural spinal tumors and their intracranial counterparts and have also identified significant variation in therapeutic effects on these tumors. This review discusses the genetic and molecular alterations in the most common intradural spinal tumors in both adult and pediatrie patients, including nerve sheath tumors (that is, neurofibroma and schwannoma), meningioma, ependymoma, astrocytoma (that is, low-grade glioma, anaplastic astrocytoma, and glioblastoma), hemangioblastoma, and medulloblastoma. It also examines the genetics of metastatic tumors to the spinal cord, arising either from the CNS or from systemic sources. Importantly, the impact of this knowledge on therapeutic options and its application to clinical practice are discussed.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Adult
Age Factors
Astrocytoma - genetics
Child
Ependymoma - genetics
Hemangioblastoma - genetics
Humans
Medulloblastoma - genetics
Meningioma - genetics
Neoplasm Grading
Neoplasm Metastasis - genetics
Nerve Sheath Neoplasms - genetics
Practice Guidelines as Topic
Prognosis
Spinal Cord - metabolism
Spinal Cord - pathology
Spinal Cord Neoplasms - classification
Spinal Cord Neoplasms - genetics
Spinal Cord Neoplasms - secondary
Spinal Cord Neoplasms - therapy
title The genetic basis of intradural spinal tumors and its impact on clinical treatment
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