Perturbation of the normal immune system in patients with CLL

Immune dysregulation is a cardinal feature of chronic lymphocytic leukemia (CLL) from its early stage and worsens during clinical observation, even in absence of disease progression. Although the mechanisms remain unclear, new insights are emerging into the complex relationship between the CLL clone...

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Veröffentlicht in:	Blood 2015-07, Vol.126 (5), p.573-581
Hauptverfasser:	Forconi, Francesco, Moss, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Agammaglobulinemia - etiology Agammaglobulinemia - immunology B-Lymphocytes - immunology Humans Immune Tolerance Immunity, Innate Infections - epidemiology Infections - etiology Infections - immunology Leukemia, Lymphocytic, Chronic, B-Cell - complications Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - therapy T-Lymphocytes - immunology Tumor Burden - immunology Tumor Escape
Online-Zugang:	Volltext
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