Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines

Neuroendocrine cancer cell lines are used to investigate therapeutic targets in neuroendocrine tumors (NET) and have been instrumental in the design of clinical trials targeting the PI3K/AKT/mTOR pathways, VEGF inhibitors, and somatostatin analogues. It remains unknown, however, whether the genomic...

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Veröffentlicht in:	Cancer genetics 2015-07, Vol.208 (7), p.374-381
Hauptverfasser:	Boora, Ganesh K, Kanwar, Rahul, Kulkarni, Amit A, Pleticha, Josef, Ames, Matthew, Schroth, Gary, Beutler, Andreas S, Banck, Michaela S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bronchial Neoplasms - genetics Bronchial Neoplasms - pathology bronchopulmonary carcinoid Cell Line, Tumor cell lines Chromosome Aberrations DNA Copy Number Variations exome Exome - genetics Genetic Predisposition to Disease - genetics Hematology, Oncology and Palliative Medicine High-Throughput Nucleotide Sequencing Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Medical Education Mutation Neuroendocrine Tumors - genetics Neuroendocrine Tumors - pathology next-generation sequencing Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pancreatic neuroendocrine tumor
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