Curcumin Attenuates Hydrogen Peroxide-Induced Premature Senescence via the Activation of SIRT1 in Human Umbilical Vein Endothelial Cells

Endothelial senescence has been proposed to be involved in endothelial dysfunction and atherogenesis. Curcumin, a natural phenol, possesses antioxidant and anti-inflammatory properties. However, the effect of curcumin on endothelial senescence is unclear. This study explores the effect of curcumin o...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2015/08/01, Vol.38(8), pp.1134-1141
Hauptverfasser:	Sun, Yueliu, Hu, Xiaorong, Hu, Gangying, Xu, Changwu, Jiang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Apoptosis beta-Galactosidase - metabolism Cell Division - drug effects Cells, Cultured Cellular Senescence - drug effects Curcuma - chemistry curcumin Curcumin - pharmacology Down-Regulation endothelial senescence Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - physiology Humans hydrogen peroxide Hydrogen Peroxide - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Oxidative Stress - drug effects Phosphorylation Plant Extracts - pharmacology RNA, Small Interfering silent information regulator 1 (SIRT1) Sirtuin 1 - metabolism
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