Erythropoietin attenuates Alzheimer-like memory impairments and pathological changes induced by amyloid β42 in mice

Abstract Amyloid beta (Aβ) is a key molecule in the neurodegenerative progression of Alzheimer׳s disease (AD). It is critical to develop a treatment that can arrest the Aβ-induced pathologic progression of AD. Erythropoietin (EPO) has various protective effects in the nervous system. However, the ef...

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Veröffentlicht in:	Brain research 2015-08, Vol.1618, p.159-167
Hauptverfasser:	Li, Yi-pei, Yang, Guo-jun, Jin, Li, Yang, Hong-mei, Chen, Jie, Chai, Gao-shang, Wang, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer׳s disease Amyloid beta-Peptides - toxicity Amyloid β Animals Apoptosis Avoidance Learning - drug effects Disease Models, Animal Electron Transport Complex I - metabolism Erythropoietin Erythropoietin - therapeutic use Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Hippocampus - drug effects Hippocampus - pathology Male Malondialdehyde - metabolism Maze Learning - drug effects Membrane Potential, Mitochondrial - drug effects Memory Disorders - chemically induced Memory Disorders - drug therapy Memory Disorders - pathology Mice Mice, Inbred C57BL Neurology Oxidative Stress - drug effects Peptide Fragments - toxicity Phosphorylation - drug effects Superoxide Dismutase - metabolism Tau tau Proteins - metabolism
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