Novel 5-functionalized-pyrazoles: Synthesis, characterization and pharmacological screening

[Display omitted] In the present study a series of O-substituted pyrazoles 7(a–f) and N-substituted pyrazoles 9(a–f) were synthesized via phase-transfer catalyzed reaction of ethyl 5-(bromomethyl)-1,3-diphenyl-1H-pyrazole-4-carboxylate 5 with various oxygen and nitrogen containing compounds in prese...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-09, Vol.25 (17), p.3671-3675
Hauptverfasser:	Doddaramappa, Shridevi D., Lokanatha Rai, K.M., Srikantamurthy, Ningaiah, Chandra, Chethan, Javarasetty
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amylases - antagonists & inhibitors alpha-Amylases - chemistry alpha-Amylases - metabolism alpha-Glucosidases - metabolism Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Catalysis Chemistry Techniques, Synthetic Drug Evaluation, Preclinical - methods Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glycoside Hydrolase Inhibitors - chemistry Glycoside Hydrolase Inhibitors - pharmacology Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Docking Simulation N-substitution NBS O-substitution Phase transfer catalysis Pyrazole-4-carboxylate Pyrazoles - chemistry Structure-Activity Relationship TBAB
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