Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

[Display omitted] Sustained proliferative capacity is a hallmark of cancer. In mammalian cells proliferation is controlled by the cell cycle, where cyclin-dependent kinases (CDKs) regulate critical checkpoints. CDK4 and CDK6 are considered highly validated anticancer drug targets due to their essent...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-09, Vol.25 (17), p.3420-3435
Hauptverfasser:	Sánchez-Martínez, Concepción, Gelbert, Lawrence M., Lallena, María José, de Dios, Alfonso
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use CDK inhibitors Cell Cycle Cyclin-Dependent Kinase Inhibitor Proteins - metabolism Humans Neoplasms - drug therapy
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