Crystallization of Probucol in Nanoparticles Revealed by AFM Analysis in Aqueous Solution

The crystallization behavior of a pharmaceutical drug in nanoparticles was directly evaluated by atomic force microscopy (AFM) force curve measurements in aqueous solution. A ternary spray-dried sample (SPD) was prepared by spray drying the organic solvent containing probucol (PBC), hypromellose (HP...

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Veröffentlicht in:	Molecular pharmaceutics 2015-08, Vol.12 (8), p.2972-2980
Hauptverfasser:	Egami, Kiichi, Higashi, Kenjirou, Yamamoto, Keiji, Moribe, Kunikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallization - methods Crystallography, X-Ray Microscopy, Atomic Force - methods Microscopy, Electron, Scanning Nanoparticles - chemistry Particle Size Probucol - chemistry Water - chemistry
Online-Zugang:	Volltext
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