Metronidazole hydrazone conjugates: Design, synthesis, antiamoebic and molecular docking studies

[Display omitted] Metronidazole hydrazone conjugates (2–13) were synthesized and screened in vitro for antiamoebic activity against HM1: IMSS strain of Entamoeba histolytica. Six compounds were found to be better inhibitors of E. histolytica than the reference drug metronidazole. These compounds sho...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-09, Vol.25 (17), p.3545-3549
Hauptverfasser:	Ansari, Mohammad Fawad, Siddiqui, Shadab Miyan, Agarwal, Subhash M., Vikramdeo, Kunwar Somesh, Mondal, Neelima, Azam, Amir
Format:	Artikel
Sprache:	eng
Schlagworte:	Amebicides - chemistry Amebicides - pharmacology Amoebiasis Drug Design Entamoeba histolytica Entamoeba histolytica - drug effects Entamoeba histolytica - enzymology Entamoebiasis - drug therapy Entamoebiasis - parasitology HeLa Cells Humans Hydrazones - chemistry Hydrazones - pharmacology Metronidazole Metronidazole - analogs & derivatives Metronidazole - pharmacology Molecular Docking Simulation MTT-assay Thioredoxin reductase Thioredoxin-Disulfide Reductase - metabolism
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